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Volume 144, Issue 2, Pages (August 2013)

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Presentation on theme: "Volume 144, Issue 2, Pages (August 2013)"— Presentation transcript:

1 Volume 144, Issue 2, Pages 669-671 (August 2013)
Uncommon Pulmonary Presentation of IgG4-Related Disease in a 15-Year-Old Boy  Massimo Pifferi, MD, PhD, Maria Di Cicco, MD, Andrew Bush, MD, Davide Caramella, MD, Marco Chilosi, MD, Attilio L. Boner, MD  CHEST  Volume 144, Issue 2, Pages (August 2013) DOI: /chest Copyright © 2013 The American College of Chest Physicians Terms and Conditions

2 Figure 1 The basal flow-volume curve (□) showed a characteristic appearance, with high flows in the central airways and an abrupt fall at the level of the peripheral airways. After 400 µg salbutamol, FEV1 and mid-expiratory flows (FEF25-75) increased by 13% and 61%, respectively, but the shape of the curve (△) did not change. F/V ex = flow/volume expiratory; F/V in = flow/volume inspiratory. CHEST  , DOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

3 Figure 2 High-resolution chest CT scan showing a symmetrical diffuse dilation of bronchi. A, Lobar. B, Segmental. CHEST  , DOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Histopathologic findings in bronchial biopsy specimen (magnification × 250 for all panels). A, Diffuse lymphoplasmacytic infiltration and moderate fibrosis by hematoxylin and eosin staining. B and C, Plasma cells infiltration, specifically identified by CD138 antibody (clone BB4). D, Marked increase in IgG4-positive plasma cells among the inflammatory infiltrates, showing a high IgG4/IgG ratio (>50%), by IgG4 immunostain (clone HP-6025). CHEST  , DOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions


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