1. Hunter Syndrome: Why We Need to Diagnose and Treat Early

3. Hunter Syndrome (MPS II)

4. Hunter Syndrome: Clinical Presentation

5. Hunter Syndrome: Major Signs and Symptoms

6. Severe Hunter Syndrome

7. Challenges of Early Diagnosis

8. Delay in Recognizing the Diagnosis

9. 'Red Flag' Signs and Symptoms of Hunter Syndrome That Occur Early in Disease Course

10. ENT and Hernia Surgeries in Children with Hunter Syndrome: Data from Hunter Outcome Survey

11. HUNTER Mnemonic Screening Instrument

12. Suspecting Hunter Syndrome to Establish an Early Diagnosis

13. Family History of Lysosomal Storage Disease

14. Hunter Syndrome: Diagnosis and Work-Up

15. Hunter Syndrome: Laboratory Diagnostic Testing

16. Diagnostic Challenge: Global Availability of Genetic Testing

17. Glycosaminoglycan Assays for MPS

18. Newborn Screening of MPS

19. Early Treatment of Hunter Syndrome[a]

20. Hunter Syndrome: Treatments

21. Challenges Related to ERT

22. Initiate ERT as Early as Possible

23. Early Treatment With ERT (<5 Years of Age): Growing Clinical Experience

24. Early Treatment With ERT (<5 Years of Age): Safety Experience

25. Severe Hunter Syndrome: CNS Involvement

26. Hunter Syndrome: CNS Symptom-Based Interventions

27. Summary: Diagnosis and Existing Treatment

28. Therapeutic prospects for patients with Hunter Syndrome

29. AIM-IT: IT Idursulfase

30. AIM-IT: Preliminary Data

31. Improving Outcomes for Patients With Hunter Syndrome

32. Multidisciplinary Management of Patients With Hunter Syndrome

33. Abbreviations