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Chapter 21 The Skin and Neurologic Disease Orest Hurko

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1 Chapter 21 The Skin and Neurologic Disease Orest Hurko
Copyright © 2014 Elsevier Inc. All rights reserved.

2 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure 21-1 Neurofibromatosis type 1: axillary freckling—a cluster of freckle-sized café- au-lait macules. (From Kurlemann G: Neurocutaneous syndromes. Handb Clin Neurol 108:513, 2012, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

3 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure 21-2 Tuberous sclerosis: ash leaf spot in Wood light. (From Kurlemann G: Neurocutaneous syndromes. Handb Clin Neurol 108:513, 2012, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

4 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure 21-3 Tuberous sclerosis: ash leaf spot and shagreen patch. (From Kurlemann G: Neurocutaneous syndromes. Handb Clin Neurol 108:513, 2012, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

5 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure 21-4 Tuberous sclerosis: nail-fold fibroma. (From Kurlemann G: Neurocutaneous syndromes. Handb Clin Neurol 108:513, 2012.) Copyright © 2014 Elsevier Inc. All rights reserved.

6 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure 21-5 Neurocutaneous melanosis. (From Jones, K: Smith’s Recognizable Patterns of Human Malformation. Saunders, Philadelphia, 2005, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

7 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure 21-6 Early cutaneous lesions of meningococcemia. (From Tyring S, Lupi O, Hengge U: Tropical Dermatology. Courtesy of Dr. Luc Van Kaer. Churchill Livingstone, New York, 2005, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

8 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure 21-7 Large 5-cm targetoid patch with central clearing, bright-red expanding border and central bite inflammation, characteristic of the erythema migrans rash of Lyme disease. (From Habif T, Campbell J, Chapman MS, et al: Dermatology DDX Deck. Saunders, Philadelphia, 2006, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

9 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure 21-8 Secondary syphilis: disseminated papular lesions. (From Tyring S, Lupi O, Hengge U: Tropical Dermatology. Courtesy of Dr. Luc Van Kaer. Churchill Livingstone, New York, 2005, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

10 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure 21-9 Secondary syphilis: hyperkeratotic lesions on palms and soles. (From Tyring S, Lupi O, Hengge U: Tropical Dermatology. Courtesy of Dr. Luc Van Kaer. Churchill Livingstone, New York, 2005, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

11 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Systemic lupus erythematosus. (From Callen J, Jorizzo J, Bolognia J, et al: Dermatological Signs of Internal Disease. Saunders, Philadelphia, 2009, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

12 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Small petechiae in an individual with thrombocytopenia. (From Callen J, Jorizzo J, Bolognia J, et al: Dermatological Signs of Internal Disease. Saunders, Philadelphia, 2009, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

13 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Sturge–Weber syndrome: port-wine stain. (From Jones K: Smith’s Recognizable Patterns of Human Malformation. Saunders, Philadelphia, 2005, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

14 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Incontinentia pigmenti (Bloch–Sulzberger) stage 3: the beginning of hyperpigmentation. (From Kurlemann G: Neurocutaneous syndromes. Handb Clin Neurol 108:513, 2012, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

15 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Incontinentia pigmenti (Bloch–Sulzberger) stage 4: hypopigmentation on the trunk. (From Kurlemann G: Neurocutaneous syndromes. Handb Clin Neurol 108:513, 2012, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

16 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Linear nevus sebaceous above the left eye near the hairline in Schimmelpenning–Feuerstein–Mims syndrome. (From Kurlemann G: Neurocutaneous syndromes. Handb Clin Neurol 108:513, 2012, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

17 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Ataxia-telangiectasia: bulbar conjunctiva. (From Jones K: Smith’s Recognizable Patterns of Human Malformation. Saunders, Philadelphia, 2005, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

18 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Infiltrated nodules of the forehead and face resulting in the leonine facies of lepromatous leprosy. (From Peters W, Pasvol G: Atlas of Tropical Medicine and Parasitology. 6th Ed. Mosby, St Louis, 2007, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

19 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Cutaneous small-vessel vasculitis was the first evidence of recurrence in this patient with Wegener’s granulomatosis. (From Callen J, Jorizzo J, Bolognia J, et al: Dermatological Signs of Internal Disease. Saunders, Philadelphia, 2009, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.

20 Copyright © 2014 Elsevier Inc. All rights reserved.
Figure Characteristic heliotrope rash of dermatomyositis on the eyelids. (From Habif T, Campbell J, Chapman MS, et al: Dermatology DDX Deck. Saunders, Philadelphia, 2006, with permission.) Copyright © 2014 Elsevier Inc. All rights reserved.


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