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Early Cognitive Decline and the Aging Brain - Overview

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Presentation on theme: "Early Cognitive Decline and the Aging Brain - Overview"— Presentation transcript:

1 Early Cognitive Decline and the Aging Brain - Overview
Dan Mungas Friday Harbor Psychometrics Workshop 2015

2 Acknowledgements Funded in part by Grant R13AG from the National Institute on Aging The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. Friday Harbor Psychometrics Workshop 2015

3 Brain diseases of aging progress gradually and over many years
Alzheimer’s has long been described as having an insidious onset with gradual progression over years Long term slowly progressive effects of cerebrovascular risk factors on the brain and cognition are now well known Framingham Heart Study Friday Harbor Psychometrics Workshop 2015

4 Model of AD progression
Jack et al., 2010 Friday Harbor Psychometrics Workshop 2015

5 Neuropsychology in age of imaging and biomarkers
Important for identifying the earliest clinical changes of diseases of aging Especially important when preventative treatments become available Early diagnosis and treatment will prevent irreversible brain injury and associated disability Friday Harbor Psychometrics Workshop 2015

6 Unanswered questions about early cognitive decline
How can cognitive tests be used to measure and characterize disease progression Are there different patterns of decline in normal cognitive aging and different diseases of aging Which cognitive abilities are most sensitive to cognitive decline associated with which diseases How do different ways of measuring cognitive abilities affect sensitivity to disease Friday Harbor Psychometrics Workshop 2015

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