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Blood vessel leakiness – how is it controlled?

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Presentation on theme: "Blood vessel leakiness – how is it controlled?"— Presentation transcript:

1 Blood vessel leakiness – how is it controlled?
Akhil Garg

2 Blood vessels and diffusion
bbc.co.uk

3 Diseases Inflammation Sepsis (widespread inflammation) Metastasis
Viral hemorrhagic infections uic.edu

4 What makes vessels leaky?
drugs could target the factors that make vessels leaky

5 Angiopoietins and Tie Helmutt, Nature Reviews Molecular Cell Biology 10,

6 ? 4 angiopoietins Ang-3 and Ang-4 Ang-2 Ang-1 Lungs only?
Lungs only?

7 Ang-3 Ang-4

8 What is the relative binding of each angiopoietin to Tie-2?

9 Surface Plasmon Resonance (SPR)
SPR absorption angle depends on metal surface Metal surface constant: Tie-2 Metal surface variable: Ang-1, Ang-2, Ang-3, Ang-4 etheses.whiterose.ac.uk

10 SPR Concepts More binding = more change in SPR absorption angle
Continuous stream of each angiopoietin

11 SPR Curves Himanen (2004), Nature Neuroscience 7:

12 What is the relative binding of each angiopoietin to Tie-2?

13 What is the relative binding of each angiopoietin to Tie-2?
What is the cellular effect of Ang-4? laughingmantis.com What is the in vivo effect of Ang-4? Wikimedia

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