1. Volume 378, Issue 9791, Pages 584-594 (August 2011)
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials 
Michael V Holmes, DLSHTM, Paul Newcombe, PhD, Jaroslav A Hubacek, PhD, Reecha Sofat, PhD, Sally L Ricketts, PhD, Jackie Cooper, MSc, Prof Monique MB Breteler, MD, Leonelo E Bautista, DrPH, Pankaj Sharma, MD, Prof John C Whittaker, PhD, Prof Liam Smeeth, FRCGP, Prof F Gerald R Fowkes, FRCPE, Prof Ale Algra, MD, Veronika Shmeleva, MD, Zoltan Szolnoki, PhD, Mark Roest, PhD, Michael Linnebank, MD, Jeppe Zacho, MD, Michael A Nalls, PhD, Andrew B Singleton, PhD, Luigi Ferrucci, MD, Prof John Hardy, PhD, Bradford B Worrall, MD, Prof Stephen S Rich, PhD, Mar Matarin, PhD, Paul E Norman, FRACS, Leon Flicker, FRACP, Prof Osvaldo P Almeida, PhD, Prof Frank M van Bockxmeer, FAHA, Prof Hiroshi Shimokata, MD, Prof Kay-Tee Khaw, FRC, Prof Nicholas J Wareham, FFPH, Prof Martin Bobak, PhD, Prof Jonathan AC Sterne, PhD, Prof George Davey Smith, DSc, Prof Philippa J Talmud, DSc, Prof Cornelia van Duijn, PhD, Prof Steve E Humphries, FRCPath, Jackie F Price, FFPH, Prof Shah Ebrahim, DM, Prof Debbie A Lawlor, PhD, Graeme J Hankey, FRACP, Prof James F Meschia, MD, Manjinder S Sandhu, PhD, Prof Aroon D Hingorani, FESC, Dr Juan P Casas, MD 
The Lancet 
Volume 378, Issue 9791, Pages (August 2011)
DOI: /S (11)
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2. Figure 1
Difference in homocysteine concentration in individuals without cardiovascular disease according to MTHFR 677C→T genotype, by probable folate status category
Large studies are those with more than 500 individuals. AANZ=America, Australia, and New Zealand.
The Lancet  , DOI: ( /S (11) )
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3. Figure 2
Odds ratio of stroke according to MTHFR 677C→T variant, by probable folate status category
Left panel compares individuals homozygous for T allele with CC participants. Right panel compares heterozygous with CC individuals. AANZ=America, Australia, and New Zealand.
The Lancet  , DOI: ( /S (11) )
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4. Figure 3
Odds ratio of stroke in large studies (≥400 stroke events) according to MTHFR 677C→T genotype, by probable folate status category
Differences in homocysteine concentration (derived from large studies; figure 1) are shown in category subheadings.
The Lancet  , DOI: ( /S (11) )
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5. Figure 4
Pooled relative risk of stroke from randomised clinical trials of homocysteine-lowering interventions in the context of genetic studies of the MTFHR 677C→T variant
RCT=randomised controlled trials. AANZ=America, Australia, and New Zealand.
The Lancet  , DOI: ( /S (11) )
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6. Figure 5
Sensitivity analyses of effect of homocysteine-lowering interventions from randomised clinical trials on risk of stroke
All analyses are random effects (DerSimonian and Laird). Number of clinical events reports stroke only as default and stroke plus TIA when specified in row title. RCT=randomised controlled trial. TIA=transient ischaemic attack. *Studies with fewer than 1000 participants were Wrone,51 Zoungas,50 Liem,42 Righetti,45 and House.49 †See webappendix p 24 for classification of risk of bias per study. ‡Studies reporting stroke and TIA separately were Righetti,45 Wrone,51 and HOPE-2.48 §Studies that used B vitamins (other than folic acid) as one of the comparator groups were Ebbing43 and Bonaa;44 studies that used low-dose folic acid as comparator group (and not placebo or standard care) were Wrone51 and Toole.54
The Lancet  , DOI: ( /S (11) )
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