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Advanced Soft Tissue Sarcoma: Current and Future
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Program Introduction
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Sarcoma Histologic Subtypes
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Molecular Subtypes of Sarcoma
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Histology Subtypes
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Drugs and Subtypes
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Advanced STS: Mono vs Poly Chemotherapy
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Doxorubicin vs Intensified Doxorubicin Plus Ifosfamide for Advanced STS: Phase 3
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Gemcitabine Plus Docetaxel vs Doxorubicin as First-Line Therapy in Metastatic STS: Phase 3 GeDDis Trial
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Systemic Therapies for Advanced Pretreated STS
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Trabectedin vs Dacarbazine in Advanced LMS and LPS: SAR-3007
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Eribulin vs Dacarbazine: Phase 3 Trial
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Pazopanib for Metastatic STS: Phase 3 PALETTE Trial
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Pazopanib in Advanced and/or Metastatic LPS: Phase 2 GEIS-30/GISG-07
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PDGFR
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PFS for Olaratumab + Doxorubicin vs Doxorubicin Alone (ITT Population)
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OS for Olaratumab + Doxorubicin vs Doxorubicin Alone (ITT Population)
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Olaratumab Safety
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Molecular Subtypes of Sarcoma
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M-CSFR Inhibitors in PVNS With t(1,2)
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Effect of RG7112 on the p53 Pathway in MDM-2 Amplified Advanced WD/DD LPS
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Palbociclib in CDK4 Amplified Advanced WD/DD LPS
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Conclusions
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