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Advanced Soft Tissue Sarcoma: Current and Future

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Presentation on theme: "Advanced Soft Tissue Sarcoma: Current and Future"— Presentation transcript:

1 Advanced Soft Tissue Sarcoma: Current and Future

2

3 Program Introduction

4 Sarcoma Histologic Subtypes

5 Molecular Subtypes of Sarcoma

6 Histology Subtypes

7 Drugs and Subtypes

8 Advanced STS: Mono vs Poly Chemotherapy

9 Doxorubicin vs Intensified Doxorubicin Plus Ifosfamide for Advanced STS: Phase 3

10 Gemcitabine Plus Docetaxel vs Doxorubicin as First-Line Therapy in Metastatic STS: Phase 3 GeDDis Trial

11 Systemic Therapies for Advanced Pretreated STS

12 Trabectedin vs Dacarbazine in Advanced LMS and LPS: SAR-3007

13 Eribulin vs Dacarbazine: Phase 3 Trial

14 Pazopanib for Metastatic STS: Phase 3 PALETTE Trial

15 Pazopanib in Advanced and/or Metastatic LPS: Phase 2 GEIS-30/GISG-07

16 PDGFR

17 PFS for Olaratumab + Doxorubicin vs Doxorubicin Alone (ITT Population)

18 OS for Olaratumab + Doxorubicin vs Doxorubicin Alone (ITT Population)

19 Olaratumab Safety

20 Molecular Subtypes of Sarcoma

21 M-CSFR Inhibitors in PVNS With t(1,2)

22 Effect of RG7112 on the p53 Pathway in MDM-2 Amplified Advanced WD/DD LPS

23 Palbociclib in CDK4 Amplified Advanced WD/DD LPS

24 Conclusions

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