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A Crystal-Clear Interaction: Relating Neuroligin/Neurexin Complex Structure to Function at the Synapse  Joshua N. Levinson, Alaa El-Husseini  Neuron 

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Presentation on theme: "A Crystal-Clear Interaction: Relating Neuroligin/Neurexin Complex Structure to Function at the Synapse  Joshua N. Levinson, Alaa El-Husseini  Neuron "— Presentation transcript:

1 A Crystal-Clear Interaction: Relating Neuroligin/Neurexin Complex Structure to Function at the Synapse  Joshua N. Levinson, Alaa El-Husseini  Neuron  Volume 56, Issue 6, Pages (December 2007) DOI: /j.neuron Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Neuroligin/Neurexin Complex at the Synapse
(A) Neuroligins (blue) dimerize through a four-helix bundle, which allows two neurexin molecules (orange) to bind the neuroligin dimer. Presence of an insert at splice site B in neuroligins (red) diminishes binding of neuroligins to α-neurexins. (B) Mutations associated with autism are predicted to disrupt neuroligin dimerization and reduce the affinity of neuroligins for neurexins. Neuron  , DOI: ( /j.neuron ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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