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Variations in GABRA2, Encoding the α2 Subunit of the GABAA Receptor, Are Associated with Alcohol Dependence and with Brain Oscillations  Howard J. Edenberg,

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Presentation on theme: "Variations in GABRA2, Encoding the α2 Subunit of the GABAA Receptor, Are Associated with Alcohol Dependence and with Brain Oscillations  Howard J. Edenberg,"— Presentation transcript:

1 Variations in GABRA2, Encoding the α2 Subunit of the GABAA Receptor, Are Associated with Alcohol Dependence and with Brain Oscillations  Howard J. Edenberg, Danielle M. Dick, Xiaoling Xuei, Huijun Tian, Laura Almasy, Lance O. Bauer, Raymond R. Crowe, Alison Goate, Victor Hesselbrock, Kevin Jones, Jennifer Kwon, Ting-Kai Li, John I. Nurnberger, Sean J. O’Connor, Theodore Reich, John Rice, Marc A. Schuckit, Bernice Porjesz, Tatiana Foroud, Henri Begleiter  The American Journal of Human Genetics  Volume 74, Issue 4, Pages (April 2004) DOI: /383283 Copyright © 2004 The American Society of Human Genetics Terms and Conditions

2 Figure 1 GABAA receptor gene cluster on chromosome 4, based on NCBI human genome build 33. Distances are in kilobases. The American Journal of Human Genetics  , DOI: ( /383283) Copyright © 2004 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Pattern of LD within GABRA2. The numbers on the X- and Y-axes correspond to 21 markers selected to cover the GABRA2 gene relatively evenly at an average spacing of 10.6 kb, plus two flanking markers; the markers are numbered in table 1. Each colored circle represents the LD between two markers, as measured by D′ (Abecasis and Cookson 2000). Higher values of D′ indicate higher LD. The American Journal of Human Genetics  , DOI: ( /383283) Copyright © 2004 The American Society of Human Genetics Terms and Conditions


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