1. Reply to Rampoldi et al. Kidney International
Yuqing Chen, Daniel T. O’Connor 
Kidney International 
Volume 84, Issue 2, Pages (August 2013)
DOI: /ki
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2. Figure 1
Uromodulin (UMOD) haplotypes in the promoter region. (a) Promoter sense strand: multiple alignment of fragments inserted into the promoter/reporter vector and the reference sequence. Promoter/reporter vectors (pGL3-Basic) containing UMOD promoter sense-strand inserts were sequence-verified. Two of the clones with the most common haplotype (TAT) and the reference sequence (NM_003361) are presented. Multiple alignment figures were shorted. Numbers shown on the right are nucleotide positions. Positions of the three proximal promoter single-nucleotide polymorphisms (sense strand: rs (T>C), rs (A>G), and rs (T>C)) are also shown. The UMOD sense-strand reference sequence (RefSeq NM_003361) was obtained from the UCSC genome database browser at genome.ucsc.edu/cgi-bin/hgGateway. (b) UMOD promoter alleles and haplotypes: statement of sense/antisense strands and clarification of nomenclature. Left: Sense-strand haplotypes (most frequent and mutant) in the pGL3-Basic vector (upon sequence verification). Sense strand: rs (T>C), rs (A>G), and rs (T>C). Right: Haplotype names used in our text and figures. The strands that gave rise to this nomenclature are as follows: rs (A>G, antisense), rs (T>C, antisense), and rs (T>C, sense).
Kidney International  , DOI: ( /ki )
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