Presentation is loading. Please wait.

Presentation is loading. Please wait.

Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA, USA

Published byOpal Higgins Modified over 5 years ago

Similar presentations

Presentation on theme: "Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA, USA"— Presentation transcript:

1 Profiles in Productivity: Greater Yield at Lower Cost with Computer DNA Interpretation
Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA, USA Barry W Duceman, PhD New York State Police, Albany, NY, USA Australia and New Zealand Forensic Science Society September, 2010 Cybergenetics © Cybergenetics ©

2 Crushing Weight of Evidence …
DNA quantity property crime, touch, … DNA quality mixed, degraded, low level, … DNA problems backlogs, low information yield … a long wait for evidence

3 TrueAllele® Casework Computer interpretation of DNA evidence
by mathematically modeling STR process Primary goals • objectivity • ease of use • information • productivity

4 Objectivity - inherent
DNA evidence data DNA evidence genotype interpret Only crime scene DNA evidence, no suspect information

5 Objectivity - inherent
suspect genotype DNA evidence data DNA evidence genotype DNA match score interpret match population genotype Objective computer interpretation of quantitative DNA evidence

6 Ease of Use - ask questions
Evidence Evidence Suspect Suspect

7 Ease of Use - get answers

8 Genotype

9 Explain Reasoning 62% 11, 12 38% 12, 13 D13S317

10 Explain Reasoning 62% 11, 12 38% 12, 13 D13S317 Data Model

11 Report suspect ethnic groups elimination

12 Report statement loci likelihood ratio genotype

13 Mixture Validation Study
368 total evidence items (Epi & Spm = 2 items) 97 Reference Samples 25 Vaginal, Anal, or Penile Swabs 39 Semen Stains 13 Clothing or Bedding 11 Weapons 69 Bloodstains 9 Fingernail Scrapings 8 Dried Secretions 32 Misc (cigarette, condom, hair, bite marks, etc.)

14 Information - reproducibility
0.036

15 Information - one unknown
17.33 4.67 12.66

16 Information - two unknown
13.26 6.24 7.03

17 Information - all mixtures

18 Productivity - item yield

19 Data Classification Mixture items assigned a degree of difficulty
Simple: two person mixture with a known victim Medium: two unknown mixture samples Complex: three or more unknown contributors, or a partial profile

20 Productivity - extra effort
Simple Medium Complex Total Number 35 20 33 88 computer log(LR) 16 13 12 14 human yield 49% 25% 21% 29% expected effort 2.1 4.0 4.7 3.4

21 Who Benefits? Probability in service to utility • Laboratory
reduce costs, increase efficiency • Society reduce crime, increase safety

22 Conclusion DNA demand workload, complexity, … DNA capacity
resources, analysts, … Automated computer interpretation • objectivity • ease of use • information • productivity

23 Acknowledgements Northeast Regional Forensics Institute Jamie Belrose
New York State Police Melissa Lee Shannon Morris Elizabeth Staude Cybergenetics William Allan Meredith Clarke Matthew Legler Jessica Smith Cara Spencer JFS Manuscript, in press Perlin, M.W., Legler, M.M., Spencer, C.E., Smith, J.L., Allan, W.P., Belrose, J.L., and Duceman, B.W. "Validating TrueAllele® DNA Mixture Interpretation," 2011.

Download ppt "Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA, USA"

Similar presentations

DNA Identification: Mixture Weight & Inference

DNA Identification: Mixture Weight & Inference
Overcoming DNA Stochastic Effects 2010 NEAFS & NEDIAI Meeting November, 2010 Manchester, VT Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA Cybergenetics.

Overcoming DNA Stochastic Effects 2010 NEAFS & NEDIAI Meeting November, 2010 Manchester, VT Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA Cybergenetics.
DNA Identification as an Information Science

DNA Identification as an Information Science
Combining DNA Evidence for Greater Match Information

Combining DNA Evidence for Greater Match Information
Finding Truth in DNA Mixture Evidence Innocence Network Conference April, 2013 Charlotte, NC Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA.

Finding Truth in DNA Mixture Evidence Innocence Network Conference April, 2013 Charlotte, NC Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA.
TrueAllele ® Challenges in Court and Culture Cybergenetics © 2003-2012 9 th Annual DNA Technology Educational Seminar Centre of Forensic Sciences and the.

TrueAllele ® Challenges in Court and Culture Cybergenetics © th Annual DNA Technology Educational Seminar Centre of Forensic Sciences and the.
How Inclusion Interpretation of DNA Mixture Evidence Reduces Identification Information American Academy of Forensic Sciences February, 2013 Washington,

How Inclusion Interpretation of DNA Mixture Evidence Reduces Identification Information American Academy of Forensic Sciences February, 2013 Washington,
Creating informative DNA libraries using computer reinterpretation of existing data Northeastern Association of Forensic Scientists November, 2011 Newport,

Creating informative DNA libraries using computer reinterpretation of existing data Northeastern Association of Forensic Scientists November, 2011 Newport,
Preventing rape in the military through effective DNA computing Forensics Europe Expo Forensics Seminar Theatre April, 2014 London, UK Mark W Perlin, PhD,

Preventing rape in the military through effective DNA computing Forensics Europe Expo Forensics Seminar Theatre April, 2014 London, UK Mark W Perlin, PhD,
Coding a Safer Society through Computer Interpretation of DNA Evidence Cybergenetics © 2003-2014 MATLAB Virtual Conference March, 2014 Mark W Perlin, PhD,

Coding a Safer Society through Computer Interpretation of DNA Evidence Cybergenetics © MATLAB Virtual Conference March, 2014 Mark W Perlin, PhD,
TrueAllele ® Interpretation of DNA Mixture Evidence 9 th International Conference on Forensic Inference and Statistics August, 2014 Leiden University,

TrueAllele ® Interpretation of DNA Mixture Evidence 9 th International Conference on Forensic Inference and Statistics August, 2014 Leiden University,
How TrueAllele® Works (Part 1)

How TrueAllele® Works (Part 1)
TrueAllele ® Casework Validation on PowerPlex ® 21 Mixture Data Australian and New Zealand Forensic Science Society September, 2014 Adelaide, South Australia.

TrueAllele ® Casework Validation on PowerPlex ® 21 Mixture Data Australian and New Zealand Forensic Science Society September, 2014 Adelaide, South Australia.
Using TrueAllele ® Casework to Separate DNA Mixtures of Relatives California Association of Criminalists October, 2014 San Francisco, CA Jennifer Hornyak,

Using TrueAllele ® Casework to Separate DNA Mixtures of Relatives California Association of Criminalists October, 2014 San Francisco, CA Jennifer Hornyak,
Kern Regional Crime Laboratory Laboratory Director: Dr. Kevin W. P. Miller TRUEALLELE® WORK AND WORKFLOW: KERN COUNTY’S FIRST CASES APRIL 23, 2014.

Kern Regional Crime Laboratory Laboratory Director: Dr. Kevin W. P. Miller TRUEALLELE® WORK AND WORKFLOW: KERN COUNTY’S FIRST CASES APRIL 23, 2014.
Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire.

Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire.
No DNA Left Behind: When inconclusive really means informative Schenectady County District Attorney’s Office January, 2014 Mark W Perlin, PhD, MD,

No DNA Left Behind: When "inconclusive" really means "informative" Schenectady County District Attorney’s Office January, 2014 Mark W Perlin, PhD, MD,
Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire.

Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire.
Solving Cold Cases by TrueAllele ® Analysis of DNA Evidence Finding Closure: The Science, Law and Politics of Cold Case Investigations October, 2014 Pittsburgh,

Solving Cold Cases by TrueAllele ® Analysis of DNA Evidence Finding Closure: The Science, Law and Politics of Cold Case Investigations October, 2014 Pittsburgh,
TrueAllele ® Mixture Interpretation Cybergenetics © 2003-2012 9 th Annual DNA Technology Educational Seminar Centre of Forensic Sciences and the Promega.

TrueAllele ® Mixture Interpretation Cybergenetics © th Annual DNA Technology Educational Seminar Centre of Forensic Sciences and the Promega.

Similar presentations

Ads by Google