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Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA, USA

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Presentation on theme: "Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA, USA"— Presentation transcript:

1 Profiles in Productivity: Greater Yield at Lower Cost with Computer DNA Interpretation
Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA, USA Barry W Duceman, PhD New York State Police, Albany, NY, USA Australia and New Zealand Forensic Science Society September, 2010 Cybergenetics © Cybergenetics ©

2 Crushing Weight of Evidence …
DNA quantity property crime, touch, … DNA quality mixed, degraded, low level, … DNA problems backlogs, low information yield … a long wait for evidence

3 TrueAllele® Casework Computer interpretation of DNA evidence
by mathematically modeling STR process Primary goals • objectivity • ease of use • information • productivity

4 Objectivity - inherent
DNA evidence data DNA evidence genotype interpret Only crime scene DNA evidence, no suspect information

5 Objectivity - inherent
suspect genotype DNA evidence data DNA evidence genotype DNA match score interpret match population genotype Objective computer interpretation of quantitative DNA evidence

6 Ease of Use - ask questions
Evidence Evidence Suspect Suspect

7 Ease of Use - get answers

8 Genotype

9 Explain Reasoning 62% 11, 12 38% 12, 13 D13S317

10 Explain Reasoning 62% 11, 12 38% 12, 13 D13S317 Data Model

11 Report suspect ethnic groups elimination

12 Report statement loci likelihood ratio genotype

13 Mixture Validation Study
368 total evidence items (Epi & Spm = 2 items) 97 Reference Samples 25 Vaginal, Anal, or Penile Swabs 39 Semen Stains 13 Clothing or Bedding 11 Weapons 69 Bloodstains 9 Fingernail Scrapings 8 Dried Secretions 32 Misc (cigarette, condom, hair, bite marks, etc.)

14 Information - reproducibility
0.036

15 Information - one unknown
17.33 4.67 12.66

16 Information - two unknown
13.26 6.24 7.03

17 Information - all mixtures

18 Productivity - item yield

19 Data Classification Mixture items assigned a degree of difficulty
Simple: two person mixture with a known victim Medium: two unknown mixture samples Complex: three or more unknown contributors, or a partial profile

20 Productivity - extra effort
Simple Medium Complex Total Number 35 20 33 88 computer log(LR) 16 13 12 14 human yield 49% 25% 21% 29% expected effort 2.1 4.0 4.7 3.4

21 Who Benefits? Probability in service to utility • Laboratory
reduce costs, increase efficiency • Society reduce crime, increase safety

22 Conclusion DNA demand workload, complexity, … DNA capacity
resources, analysts, … Automated computer interpretation • objectivity • ease of use • information • productivity

23 Acknowledgements Northeast Regional Forensics Institute Jamie Belrose
New York State Police Melissa Lee Shannon Morris Elizabeth Staude Cybergenetics William Allan Meredith Clarke Matthew Legler Jessica Smith Cara Spencer JFS Manuscript, in press Perlin, M.W., Legler, M.M., Spencer, C.E., Smith, J.L., Allan, W.P., Belrose, J.L., and Duceman, B.W. "Validating TrueAllele® DNA Mixture Interpretation," 2011.

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