1. Effect of Carbonation on Brain Processing of Sweet Stimuli in Humans
Francesco Di Salle, Elena Cantone, Maria Flavia Savarese, Adriana Aragri, Anna Prinster, Emanuele Nicolai, Giovanni Sarnelli, Maurizio Iengo, Maxime Buyckx, Rosario Cuomo 
Gastroenterology 
Volume 145, Issue 3, Pages e3 (September 2013)
DOI: /j.gastro
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2. Figure 1
Effect of carbonation on neural activity. (A) The presence of carbonation independently of the sweetening agent reduced (blue-green) activity in the AI, OFC, SFG, PTC, OTC, and MFG and increased activity in OTC. (B) With sucrose, CO2 reduced activity in the PTC, AI, OFC, IFG, MFG, and OTC. (C) With As-Ac, CO2 increased activity in the OTC. IFG, inferior frontal gyrus; MFG, middle-frontal gyrus; OTC, occipitotemporal cortex; PTC, posterior-temporal cortex; SFG, superior frontal gyrus.
Gastroenterology  , e3DOI: ( /j.gastro )
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3. Figure 2
Effect of the sweetening agent. (A) Independently of carbonation, sucrose increased (yellow-red) activity in Amy and As-Ac increased activity in AI. (B) Differential brain activity for sucrose versus As-Ac was more evident without than with CO2 and diffusely in favor of sucrose (left OTC, MTC, and OFC). (C) CO2 reduced differential brain activity, which was higher for As-Ac in AI, OTC, ITC, and OFC. ITC, inferior temporal cortex; MTC, mesial-temporal cortex; OTC, occipitotemporal cortex.
Gastroenterology  , e3DOI: ( /j.gastro )
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4. Supplementary Figure 1
(A) Perception of sweetness in 14 healthy volunteers during administration of carbonated or noncarbonated Sprite beverages sweetened with As-Ac or sucrose. (B) Perception of sweetness in 7 healthy volunteers during administration of carbonated or noncarbonated 10% glucose solution. Data are represented as individual values and mean ± SD.
Gastroenterology  , e3DOI: ( /j.gastro )
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5. Supplementary Figure 2
The peaks of brain activity related to carbonation and to sour taste compared with a baseline of water are represented on the partially inflated surface of brain hemispheres. Both tastes evoked neural activity with 2 distinct maxima in the insular cortex (P = .05 correlation). Two peaks are located in the insular sulcus and appear partially overlapping, and 2 peaks are located in the insular gyri and are well separated from each other.
Gastroenterology  , e3DOI: ( /j.gastro )
Copyright © 2013 AGA Institute Terms and Conditions