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The “dangers” of chronic proton pump inhibitor use

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1 The “dangers” of chronic proton pump inhibitor use
Rena Yadlapati, MD, MSHS, Peter J. Kahrilas, MD  Journal of Allergy and Clinical Immunology  Volume 141, Issue 1, Pages (January 2018) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Mechanisms of potential risks associated with PPIs. Blue boxes represent effects that are observed. Green boxes represent effects that are weakly associated with PPI use. Pink boxes represent hypothetical effects that have not been reported or observed in association with PPI use. Black arrows are established linkages, whereas red arrows are proposed unproved links. ECL, Enterochromaffin-like; SBP, spontaneous bacterial peritonitis; SIBO, small intestinal bacterial overgrowth. Journal of Allergy and Clinical Immunology  , 79-81DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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