1. Managing Hereditary Angioedema

3. Setting the Stage Burden of Disease in HAE

4. Burden of Disease in HAE (cont)

5. C1 Esterase Inhibitor for Treatment of Laryngeal Attacks in HAE

6. Other Therapies Approved For On-Demand Treatment of HAE Attacks

7. Ecallantide Efficacy

8. Icatibant FAST-3 Trials

9. Icatibant Reinjection Rates

10. C1 Inhibitor Use in Children

11. C1 Inhibitor Use in Children (cont)

12. C1 Inhibitor Use in Children for Short-term Prophylaxis

13. MacGinnitie et al Study of Ecallantide Treatment for Pediatric HAE

14. Treatment Outcomes With Ecallantide vs Placebo

15. C1 Inhibitor Dose-escalation Study

16. C1 Inhibitor Dose-escalation Study (cont)

17. The Successes in 14 Patients

18. Treatment Failures

19. Impact of HAE Prophylaxis on QoL

21. Effects of C1 Inhibitor Prophylaxis vs On-demand Therapy on QoL

22. SF-36 Norm-based Domain and Component Summary Scores

23. Recommendations for Managing HAE

24. Recommendations for Managing HAE (cont)

27. Abbreviations

28. References

29. References (cont)

30. References (cont)

31. References (cont)