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Neurogenic Orthostatic Hypotension: Expert Perspectives on Diagnosis and Treatment Strategies.

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Presentation on theme: "Neurogenic Orthostatic Hypotension: Expert Perspectives on Diagnosis and Treatment Strategies."— Presentation transcript:

1 Neurogenic Orthostatic Hypotension: Expert Perspectives on Diagnosis and Treatment Strategies

2

3 Neurogenic Orthostatic Hypotension

4 Non-neurologic Causes of OH

5 Causes of nOH Impairment of Norepinephrine Release on Standing

6 Differential Diagnosis

7 Nocturnal Hypertension Is a Common Problem in nOH Patient Populations

8 Pronounced BP Variability

9 Neurotransmitter Disorders

10 Clinical Parameters

11 Nonpharmacologic Treatment Options

12 Pharmacologic Treatment Options

13 Orthostatic Hypotension Questionnaire (OHQ)

14 Study 301 Key Inclusion and Exclusion Criteria

15 Study 301 (cont) OHQ Composite Score After 1 Week

16 Study 301 (cont) Increase in Standing BP

17 Study 306B in Patients With PD and nOH Primary Outcome Measure: Dizziness/Lightheadedness

18 Cardiovascular Disorders in Droxidopa Studies

19 Falls Related to Droxidopa vs Placebo in Study 306B

20 Management of Supine Hypertension

21 Droxidopa vs Levodopa

22 Benefit-Risk Conclusion for Droxidopa in Patients With nOH

23 Abbreviations

24 References

25 References (cont)


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