1. Surface Coatings
Frequently, presenters must deliver material of a technical nature to an audience unfamiliar with the topic or vocabulary. The material may be complex or heavy with detail. To present technical material effectively, use the following guidelines from Dale Carnegie Training®.
Consider the amount of time available and prepare to organize your material. Narrow your topic. Divide your presentation into clear segments. Follow a logical progression. Maintain your focus throughout. Close the presentation with a summary, repetition of the key steps, or a logical conclusion.
Keep your audience in mind at all times. For example, be sure data is clear and information is relevant. Keep the level of detail and vocabulary appropriate for the audience. Use visuals to support key points or steps. Keep alert to the needs of your listeners, and you will have a more receptive audience.
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2. General strategies to Prevent Device-related Infections
Minimize contact- Clean Room Conditions
Kill every thing in contact-Sterilization
Minimize binding at contact-Surface coating
Kill after contact-Anti-infective coatings
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3. Protein Adsorption in situ
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4. Protein Adsorption in situ
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11. No Protein Adsorption
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12. Surface Coating Technology
Change surface chemistry without changing mechanical properties;
Alter binding properties for proteins and other molecules to improve device performance;
Surface coating technology increases range of performance and, in general, requires less capital investment and less dramatic changes in manufacturing practices.
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13. Methods
Plasma or corona treatment in the presence of a reactive atmosphere;
Adsorption; and,
Covalent Immobilization
The objective is to create a minimally reactive surface by creating an interface that is invisible to the system or one that is specifically activated to control cell behavior at the interface.
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14. Surface Modification Using Low-Pressure Plasma Technology
A plasma is a partially ionized gas containing ions, electrons, atoms, and neutral species.
Although many gases can be used, commonly selected gases or mixtures of gases for plasma treatment of polymers include oxygen, argon, nitrous oxide, tetrafluoromethane, and air.
high-frequency generator ionizes the gas into plasma that formed reactive particles react in a direct way with the surface without damaging the bulk properties of the treated part, the surface modification is limited to the outermost 10 to 1000 Å of the substrate.
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15. PLASMA APPLICATIONS
Surface modification using gas plasma is a versatile process, with systems on the market capable of treating everything from small components like hubs or balloons up to very large and complex substrates, from fibers, nonwovens, wovens, and paper to plastic foils and metal and ceramic parts
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16. Surface Energy (dynes/cm) Water Contact Angle (degrees)
Materials
Surface Energy (dynes/cm)
Water Contact Angle (degrees)
before
after
Hydrocarbons
Polypropylene 29
>73 87 22
Polyethylene 31 42
Polystyrene 38
72.5 15
ABS 35 82 26
Polyamide/ polyethylene copolymer
<36 63 17
Epoxy 59
12.5
Polyester 41 71 18
Rigid PVC 39 90
Phenolic
None
36.5
Fluorocarbons
Polytetrafluoroethylene/ polyethylene copolymer 37 92 53
Fluorinated ethylene propylene 72 96 68
Polyvinylidene 25
78.5 36
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Table I. Typical material surface-tension and contact-angle values

17. Surfactant-based Biomaterial Coating
PEO
PPO
PEO HO OH
129 56
129
-CH2-CH2-O-
-CH-CH2-O- |
CH3
F108 coating
ca. 14 nm
Hydrophobic
Substrate
Contact angle >70°

18. Inhibition of Cell Attachment
GFAP: Green
Light Micrograph
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19. Phospholipids
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21. Phosphorylcholine Derivatives
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25. Covalent Immobilizaiton
Heparin coated after blood exposure
Uncoated after blood exposure with microthrombus on surface
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26. Emerging Technologies
Coatings for enhanced imaging
Cell coated grafts for tissue engineering
Coating to enhance regenerative processes
Coatings for drug delivery
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27. Coating Companies
Polymer Technology Group SurModics Carmeda Hydromer Inc. AST Products Inc. STS Biopolymers Biocoat Richard James Inc. Biocompatibles Ltd. BioChrom Surface Solutions Laboratories Spire Corp. Implant Sciences Corp. Advanced Polymer Systems Inc.
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