1. Staying on Course: Optimizing Antiepileptic Medication Regimens

3. Program Overview

4. The Burden of Epilepsy

5. AEDs and Switching

6. MHRA Safety Update in the United Kingdom: Risk-Based Categories for Switching Products

7. AEDs: Different Preparations

8. Adverse Effects of AEDs

9. Pharmacologic Factors

10. Bioequivalence vs Therapeutic Equivalence: Regulations Covering Licensing of Generic Products

11. Issues of Concern About Generic Substitution of AEDs Identified in a Literature Review

12. Survey of Neurologists on Experience With Switching Patients to a Generic AED

13. Breakthrough Seizures Can Affect Patient QoL

14. Consequences of Generic AED Substitution: Survey of Neurologists

15. Design of AED Switching Studies

16. Comparative Effectiveness of Brand vs Generic AEDs

17. Meta-analysis of 7 RCTs of Brand vs Generic AEDs: Odds of Uncontrolled Seizure

18. Odds of a Seizure-Related Event Higher in Patients Switching Between Bioequivalent AEDs

19. Association Between AED Refill and Switch and Seizure-Related Events

20. Studies of Switching Back From a Generic to a Brand AED

21. Evidence for 2 Seizure-Free Years Before Withdrawing AEDs in Children

22. AED Substitution: International Experience

23. Factors Affecting Seizure Control

24. Take-Home Messages

25. Abbreviations