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Proposed model of a mechanosensor in VSMCs This model is based on the mechanotransducer model established in the nematode. The mechanosensor may be a heteromultimeric.

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Presentation on theme: "Proposed model of a mechanosensor in VSMCs This model is based on the mechanotransducer model established in the nematode. The mechanosensor may be a heteromultimeric."— Presentation transcript:

1 Proposed model of a mechanosensor in VSMCs This model is based on the mechanotransducer model established in the nematode. The mechanosensor may be a heteromultimeric complex. ENaC and/or ASIC proteins form the ion-transducing heart of the mechanotransducer. These proteins are anchored to the extracellular matrix and cytoskeleton by associated linking proteins and are yet to be identified. The application of a mechanical stimulus, such as strain, gates channel activity and allows influx of Na+/Ca2+. ©2008 by American Physiological Society

2 Proposed model of a mechanosensor
Proposed model of a mechanosensor in VSMCs This model is based on the mechanotransducer model established in the nematode. The mechanosensor may be a heteromultimeric complex. ENaC and/or ASIC proteins form the ion-transducing heart of the mechanotransducer. These proteins are anchored to the extracellular matrix and cytoskeleton by associated linking proteins and are yet to be identified. The application of a mechanical stimulus, such as strain, gates channel activity and allows influx of Na+/Ca2+. Heather A. Drummond et al. Physiology 2008;23:23-31 ©2008 by American Physiological Society

3 Proposed model of a mechanosensor in VSMCs This model is based on the mechanotransducer model established in the nematode. The mechanosensor may be a heteromultimeric complex. ENaC and/or ASIC proteins form the ion-transducing heart of the mechanotransducer. These proteins are anchored to the extracellular matrix and cytoskeleton by associated linking proteins and are yet to be identified. The application of a mechanical stimulus, such as strain, gates channel activity and allows influx of Na+/Ca2+. ©2008 by American Physiological Society

4 Proposed model of a mechanosensor in VSMCs This model is based on the mechanotransducer model established in the nematode. The mechanosensor may be a heteromultimeric complex. ENaC and/or ASIC proteins form the ion-transducing heart of the mechanotransducer. These proteins are anchored to the extracellular matrix and cytoskeleton by associated linking proteins and are yet to be identified. The application of a mechanical stimulus, such as strain, gates channel activity and allows influx of Na+/Ca2+. ©2008 by American Physiological Society

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