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Transcriptional control: Tat cofactors and transcriptional elongation

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Presentation on theme: "Transcriptional control: Tat cofactors and transcriptional elongation"— Presentation transcript:

1 Transcriptional control: Tat cofactors and transcriptional elongation
Krassimir Yankulov, David Bentley  Current Biology  Volume 8, Issue 13, Pages R447-R449 (June 1998) DOI: /S (98)

2 Figure 1 Cyclin T binds directly to the Tat activation domain, conferring tight binding to TAR RNA and recognition of the loop [6]. Current Biology 1998 8, R447-R449DOI: ( /S (98) )

3 Figure 2 (a) A model for the two-stage phosphorylation of RNA polymerase CTD, first by TFIIH and then by Cdk9–cyclin T (P-TEFb). (b) Tat binding to P-TEFb and TFIIH may enhance the efficiency of CTD phosphorylation, launching highly processive polymerase II elongation complexes. Current Biology 1998 8, R447-R449DOI: ( /S (98) )


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