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Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation 

Published byMaría Cristina Ramos Villalobos Modified over 6 years ago

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Presentation on theme: "Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation "— Presentation transcript:

1 Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation  Kana Kitamura, MD, Hideo Asada, MD, PhD, Hideyuki Iida, MD, Takaya Fukumoto, MD, PhD, Nobuhiko Kobayashi, MD, PhD, Hironori Niizeki, MD, PhD, Takeshi Morii, MD, PhD, Hiroshi Kimura, MD, PhD, Sachiko Miyagawa, MD, PhD  Journal of the American Academy of Dermatology  Volume 58, Issue 5, Pages (May 2008) DOI: /j.jaad Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Case 8. Clinical and histologic findings. A and B, Macular/papular rash on trunk, appearing on day 32 after allo-SCT. C and D, Sparse lymphocytic infiltration of upper dermis with exocytosis of lymphocytes into epidermis. (C and D, Hematoxylin-eosin stain; original magnifications: C,×100; D, ×200.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Case 7. Clinical and histologic findings. A and B, Acute disseminated macular/papular rash, appearing on day 27 after allo-SCT. C and D, Established acute GVHD of the skin. Lymphocytic interface dermatitis and multiple eosinophilic keratinocytes. (C and D, Hematoxylin-eosin stain; original magnifications: C, ×100; D, ×200.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 HHV-6 DNA levels in the whole blood (solid circle) and sera (open circle), hepatic enzyme (triangle), and rash (shaded area) after allo-SCT. Dagger indicates death of patient. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 4 Relationship among serum IL-10 (picograms per milliliter of serum) and sIL-2R levels (units per milliliter of serum), HHV-6 DNA levels (number of copies per 106 lymphocytes), and rash. Dagger indicates death of patient. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

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