1. Summary of Change From Baseline in Type 2 Diabetes Parameters at 12 Months*
Nilotinib 300 mg bid
Nilotinib 400 mg bid
Imatinib 400 mg qd n
Median
Range
Weight, kg 16
0.4
(-15 – 6.1) 13 -5
(-11.3 – 5) 10
1.9
(-11.8 – 9.6)
A1C, % 17
0.3
(-1.7 – 1.4)
0.2
(-1.4 – 2.9) 8
-0.8
(-2.7 – 0.6)
FBG, mmol/L
0.8
(-4.8 – 4.7)
(-4.3 – 10.5)
-0.25
(-3.4 – 2.6)
Insulin, pmol/L
1.7
(-341 – 41) 12
6.1
(-76 – 122) 9
-2.6
(-277 – 257)
C-peptide, nmol/L
-0.15
(-3.03 – 0.12)
-0.12
(-1.99 – 1.63)
-0.24
(-1.57 – 1.34)
*Includes only evaluable patients with assessments at baseline and at 12 months
Bid=twice daily; FBG=fasting blood glucose; qd=once daily
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