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Activity of imipenem against VIM-1 metallo-β-lactamase-producing Klebsiella pneumoniae in the murine thigh infection model  G.L. Daikos, A. Panagiotakopoulou,

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Presentation on theme: "Activity of imipenem against VIM-1 metallo-β-lactamase-producing Klebsiella pneumoniae in the murine thigh infection model  G.L. Daikos, A. Panagiotakopoulou,"— Presentation transcript:

1 Activity of imipenem against VIM-1 metallo-β-lactamase-producing Klebsiella pneumoniae in the murine thigh infection model  G.L. Daikos, A. Panagiotakopoulou, E. Tzelepi, A. Loli, L.S. Tzouvelekis, V. Miriagou  Clinical Microbiology and Infection  Volume 13, Issue 2, Pages (February 2007) DOI: /j x Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 In-vivo killing kinetics of a non-VIM-producing Klebsiella pneumoniae strain (Kp-S), and VIM-1-producing K. pneumoniae strains (Kp-Ia, Kp-Ib and Kp-R) in the thighs of neutropenic mice treated with imipenem 30 mg/kg (scheme A) or 60 mg/kg (scheme B) every 2 h. Bacterial growth in untreated animals is also shown. 0 h represents the time of initiation of treatment. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions


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