1. Migraine
Poorly understood neurovascular disease caused by neurogenic inflammation and characterized by extremely severe recurring headaches affects about 15% population
More often affects women (3:1 F:M)
Unknown etiology although serotonin (5HT) is important mediator. Many environmental triggers
Smoke, noises, stress, lights
Serotonin regulates
Vasodilation (Decreased 5HT)
Vasoconstriction (Increased 5HT)
Treatments
Abortive when migraine occurs
Pain killers, ibuprofen, NSAIDS,
Prophylactic when abortive treatment does not work
beta andrenergic blockers, metaprolol, nadodol, 5Ht antgonists (Ergatol etc)

4. Team Workshop 1: Ergotamine is used to treat migraine
Team Workshop 1: Ergotamine is used to treat migraine. What is the MOA of ergotamine and list two reasons it is a preferred drug compared to 5HT?

5. Team Workshop 2: Current research has suggested that migraine and seizures are different manifestations of a similar disease. Use your tools to propose a molecular and anatomical basis for how they are related and provide evidence to support your proposal.