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Defensins Deisy Cifuentes Mr.Trefz Genetics.

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Presentation on theme: "Defensins Deisy Cifuentes Mr.Trefz Genetics."— Presentation transcript:

1 Defensins Deisy Cifuentes Mr.Trefz Genetics

2 Amino-acid sequence They consist of amino-acids including six (in vertebrates) to 8 conserved cyteine residues.

3 Structures Quaternary protein structure
B-sheet structures are indicated by flat ribbons and arrows. Human neutrophil peptide 3 (HNP3, a-defensin) forms a b-sheet-rich dimer

4 Tetiary Protein Structure
Human B-defensin 2 (HBD2) in solution is a monomer with the same general shape (defensin-fold) despite the change of the disulphide-bond pattern

5 Tertiary protein structure
Has a B-helical segment that is linked by two disulphide bonds .

6 Function Defensins are active against bacteria , fungi and many enveloped and nonenveloped viruses. Cells of the immune system contain the peptides mentioned before and they kill phagocytized bacteria.

7 Other organism that use Defensins
Vertebrates, invertebrates and plants.

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