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Atsushi Tanaka, Richard J. Youle  Molecular Cell 

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1 A Chemical Inhibitor of DRP1 Uncouples Mitochondrial Fission and Apoptosis 
Atsushi Tanaka, Richard J. Youle  Molecular Cell  Volume 29, Issue 4, Pages (February 2008) DOI: /j.molcel Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic of DRP1 Assembly on the Mitochondrial Outer Membrane during Apoptosis Followed by Mitochondrial Constriction Driven by Either Assembly, GTP Hydrolysis, or Both and Finally Cytochrome c Release Bax and Bak coassemble with DRP1 and mediate MOMP in the last frame. Mdivi-1 inhibits the first step of DRP1 assembly. Abbreviations include the following: MOM, mitochondrial outer membrane; IMS, intermembrane space, MIM, mitochondrial inner membrane; Cyt-c, cytochrome c; and MOMP, mitochondrial outer membrane permeabilization. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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