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Ring around the Ro-sie: RNA-Mediated Alterations of PNPase Activity

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Presentation on theme: "Ring around the Ro-sie: RNA-Mediated Alterations of PNPase Activity"— Presentation transcript:

1 Ring around the Ro-sie: RNA-Mediated Alterations of PNPase Activity
Brian J. Geiss, Jeffrey Wilusz  Cell  Volume 153, Issue 1, Pages (March 2013) DOI: /j.cell Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Regulation of Protein Function by RNA Cofactors
Noncoding RNAs can change the “perspective” of protein enzymes through the formation of ribonucleoprotein complexes. On the left, a PNPase (and perhaps other cellular ribonucleases) has little ability to discriminate between different types of RNA substrates. On the right, after formation of an RNP structure in which the noncoding Y RNA bridges an interaction between the Ro protein (the lens of the monocle) and PNPase, the enzyme is able to distinguish structured RNAs more clearly and is much more selective regarding the type of RNA substrate that it prefers. Cell  , 12-14DOI: ( /j.cell ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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