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DNMT1 and Cancer: An Electrifying Link

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1 DNMT1 and Cancer: An Electrifying Link
Nicole N. Nuñez, Amelia H. Manlove, Sheila S. David  Chemistry & Biology  Volume 22, Issue 7, Pages (July 2015) DOI: /j.chembiol Copyright © 2015 Elsevier Ltd Terms and Conditions

2 Figure 1 DNA Charge Transport Based Sensor for Measuring Levels of DNA Methylation (A) The DNA “wire” is not methylated in the presence of normal cell extracts, leaving it susceptible to cleavage by the restriction enzyme (BssHII), which eliminates the electrochemical current. (B) DNA methylation by tumor cell extracts protects the DNA “wire” and maintains the electrochemical signal (represented by the lit bulb). Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2015 Elsevier Ltd Terms and Conditions


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