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Central Dogma Goes Digital

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1 Central Dogma Goes Digital
Yihan Lin, Michael B. Elowitz  Molecular Cell  Volume 61, Issue 6, Pages (March 2016) DOI: /j.molcel Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Digital Quantification of Both mRNA and Protein in the Same Cell (A) A method for quantifying mRNA and protein molecules in individual cells. Single mammalian cells are sorted and lysed. The lysate is split into two fractions for protein and mRNA quantification, respectively. Protein copy number is quantified by proximity ligation assay followed by droplet digital PCR (top). mRNA copy number is quantified by reverse transcription followed by droplet digital PCR (bottom). (B) The correlation between mRNA and protein copy numbers (schematic) can provide insights into the mechanisms underlying gene expression. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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