1. SIRS Systemic Inflammatory Response Syndrome
Building Blocks of Knowledge

2. SIRS Building Blocks of Knowledge
SIRS is nonspecific
Bacteremia
ACCP offered this definition of SIRS:
Fever > OR < 96.6
HR > 90
RR > 20 OR PaCO2 < 32
WBC >12, <4, or 10% immature
Can be caused by:
Ischemia
Inflammation
Infection
Trauma
Or a combination of insults
Is the presence of bacteria within the bloodstream, but does not always lead to SIRS or Sepsis.
Sepsis is the systemic response to infection and is defined as the presence of SIRS in addition to a documented or suspected or presumed infection.

3. SIRS Building Block of Knowledge
Infection triggers an inflammatory response * Redness, swelling heat and pain are present locally If homeostasis is not achieved, the inflammatory response will cross over into the circulation, and a significant inflammatory reaction begins to cascade

4. SIRS Building Blocks of Knowledge
The consequence of this is a loss of circulatory integrity due to cell destruction * Capillary’s leak, microvascular thrombus develop, tissue hypoxia, cell death, impaired vascular … Leading to Multiple Organ Dysfunction

5. SIRS Building Blocks of Knowledge
Multiple Organ Dysfunction Syndrome is a process, not an event
Characterized by the development of progressive physiologic dysfunction in two or more organs or organ systems
No organ system is immune
Mortality increases as organ failure increases
Mortality ranges from 40-75% in patients with MODS arising from sepsis

6. SIRS Building Blocks of knowledge
Time Early Recognition Early Intervention (antibiotics, fluids) SUSPECT SEPSIS. SAVE LIVES.