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A Comparison of the Pharmacokinetics, Clinical Efficacy, and Tolerability of Once-Daily Tramadol Tablets with Normal Release Tramadol Capsules  Bhavesh.

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Presentation on theme: "A Comparison of the Pharmacokinetics, Clinical Efficacy, and Tolerability of Once-Daily Tramadol Tablets with Normal Release Tramadol Capsules  Bhavesh."— Presentation transcript:

1 A Comparison of the Pharmacokinetics, Clinical Efficacy, and Tolerability of Once-Daily Tramadol Tablets with Normal Release Tramadol Capsules  Bhavesh Bodalia, MB ChB, DRCOG, Chris J McDonald, MB BS, MRCOphth, FFPM, Kevin J Smith, BSc (Hons), PhD, Catherine O'Brien, BSc (Hons), Lois Cousens, BSc (Hons)  Journal of Pain and Symptom Management  Volume 25, Issue 2, Pages (February 2003) DOI: /S (02)

2 Fig. 1 Plasma tramadol and O-desmethyltramadol profiles at steady-state for volunteers receiving OD tablet 150 mg (triangle), OD tablet 200 mg (square), or NR capsule 50 mg (bar). Journal of Pain and Symptom Management  , DOI: ( /S (02) )

3 Fig. 2 Disposition of patients enrolled in the clinical study. A = OD tablet 150 mg, B = OD tablet 200 mg, and C = NR capsule 50 mg. Journal of Pain and Symptom Management  , DOI: ( /S (02) )

4 Fig. 3 Adjusted mean treatment differences in VAS pain scores (95% confidence intervals). A = OD tablet 150 mg, B = OD tablet 200 mg, and C = NR capsule 50 mg. Journal of Pain and Symptom Management  , DOI: ( /S (02) )


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