1. Cast Nephropathy and Deceptively Low Absolute Serum Free Light Chain Levels: Resolution of a Challenging Case and Systematic Review of the Literature 
Michael P. Rassner, Maximilian Seidl, Ulrich Salzer, S. Vincent Rajkumar, Thomas Epting, Ralph Wäsch, Elke Neumann-Haefelin, Monika Engelhardt 
Clinical Lymphoma, Myeloma and Leukemia 
Volume 18, Issue 1, Pages e1-e7 (January 2018)
DOI: /j.clml
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
A, Protein Electrophoresis: No Distinct M-gradient Was Detected. Serum (B) and Urine (C) Immunofixations Illustrate IgG, IgA, IgM, and κ-and λ-Light Chain Levels. The Arrows Indicate the κ-Free Light Chain. D, Periodic Acid-Schiff Staining Displays an Atypic, Periodic Acid–Schiff-Positive Cast (Asterisk) With a Giant Cell (Arrowheads). Acute Damage of the Surrounding Tubular Epithelium, Which Is Flattened and Shows Vacuolization as Well as Loss of Brush Borders. E, Ultrastructural Analysis by Electron Microscopy Highlights Osmiophilic Serum in the Capillary Lumina (Asterisk), Suggestive of High Light Chain Amounts. Owing to Slight Variations in the Optical Density of the Basement Membrane (Black Arrowhead: Higher Density), Minor Clinically Insignificant Light Chain Deposition in the Basement Membrane Could Not Be Ruled Out
Clinical Lymphoma, Myeloma and Leukemia  , e1-e7DOI: ( /j.clml )
Copyright © 2017 Elsevier Inc. Terms and Conditions