1. Mortality risk associated with renal insufficiency in women with HF and coronary disease
Creatinine clearance (mL/min) n
All-cause mortality (%)
Adjusted HR* (95% CI)
>60
297
13.1
1.0
40-60
283
33.2
1.53
( )
<40
122
53.3
2.40
( )
*Adjusted for demographic features, major comorbidities, and LVEF
Bibbins-Domingo K et al. J Am Coll Cardiol 2004; 44:

2. Mortality risk associated with renal insufficiency in women with HF and coronary disease by ACE inhibitor use
Creatinine clearance (mL/min)
With ACE inhibitors, adjusted HR* (95% CI)
Without ACE inhibitors, adjusted HR* (95% CI)
>60
1.0
40-60
0.9 ( )
2.1 ( )
<40
1.7 ( )
3.1 ( )
*Adjusted for demographic features, major comorbidities, LVEF, and use of beta blockers, aspirin, calcium channel blockers, diuretics, digoxin, and statins
Bibbins-Domingo K et al. J Am Coll Cardiol 2004; 44: