1. Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.122
Figure 1 Brain pathways, regions and networks involved in acute and chronic pain
Figure 1 | Brain pathways, regions and networks involved in acute and chronic pain. a | Major ascending (bottom-up) pathways from the spinal cord to the brain that are activated by noxious stimuli (left) and descending (top-down) pathways that modulate transmission of ascending nociceptive signals (right). b | Key brain areas, resting state functional networks and white matter in which activity is often found to be abnormal in chronic pain. Permission for part a left panel obtained from John Wiley and Sons © Apkarian, A. V. et al. Eur. J. Pain 9, 463–484 (2005). Permission for part a right panel obtained from the American Society for Clinical Investigation © Schweinhardt, P. & Bushnell, C. J. Clin. Invest. 120, 3788–3797 (2010).
Permission for part a left panel obtained from John Wiley and Sons © Apkarian, A. V.
et al. Eur. J. Pain 9, 463–484 (2005). Permission for part a right panel obtained from the American
Society for Clinical Investigation © Schweinhardt, P. & Bushnell, C. J. Clin. Invest. 120, 3788–3797 (2010)
Davis, K. D. et al. (2017) Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations
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