1. Chair and Discussant: Karla Hemming University of Birmingham
Recent Developments in the Design and Analysis of Cluster Randomized Controlled Trials Society of Clinical Trials and International Methodology Conference May 9th 2017
Introduction to me..
Thanks so much for the invitation.
Love study design, particularly experimental design
Background and lots of training at LSHTM
Will give a little introduction to my academic home
Am asst prof of Biostatistics and Global Health
Chair and Discussant: Karla Hemming
University of Birmingham

2. Session Summary

3. CRT Design and Analysis
Talk 1
Talk 2
Talk 3

4. Talk 1 – Developments in Design (Liz)
Design Challenges – Focus: Parallel-Arm
Clustering
Change in individuals or in populations
Baseline imbalance: Cluster Size & Covariates
Power and Sample Size
Alternatives to the Parallel-Arm CRT
Crossover CRT
Stepped Wedge CRT
Pseudo-Cluster Trial
Individually-Randomized Group Treatment Trial

5. Talk 2 – Linking Design to Analysis (Fan)
Focus: baseline covariate balance
Design-based strategies
Matching
Stratification
Covariate-Constrained Randomization
Analysis-based strategies
Match analysis to the design

6. Talk 3 – Developments in Analysis (Melanie)
Focus: Population-averaged effects
Considerable developments in past 10 yrs
Statistical Methods
GEE
Alternatives to GEE
QIF (quadratic inference function)
tMLE (targeted maximum likelihood)
Augmented GEE

7. Any questions or comments?
Online first - American Journal of Public Health
Any questions or comments?