1. Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic lymphoma in childhood and adolescence
by Bettina R. Bonn, Marius Rohde, Martin Zimmermann, David Krieger, Ilske Oschlies, Felix Niggli, Grazyna Wrobel, Andishe Attarbaschi, Gabriele Escherich, Wolfram Klapper, Alfred Reiter, and Birgit Burkhardt
Blood
Volume 121(16):
April 18, 2013
©2013 by American Society of Hematology

2. Overview about the mutations found in NOTCH1.
Overview about the mutations found in NOTCH1. The domain structure of NOTCH1, the functions of these domains, and the respective coding exons are schematically depicted (A). Analyzed exons and domains are highlighted. Mutations detected in this study are illustrated with respect to their position in the exons of the gene (B). Symbols below the exon line indicate homozygous mutation. Modified after Weng et al9, Zuurbier et al14, and Wagener and Müller.35 EGF, epidermal growth factor; HD, heterodimerization domain; LNR, LIN12/NOTCH repeats; NLS, nuclear localization sequence; TAD, transactivation domain. TM, transmembrane domain.
Bettina R. Bonn et al. Blood 2013;121:
©2013 by American Society of Hematology

3. Five-year probability of EFS (A) and 5-year cumulative incidence of nonresponse/progression/relapse (B), according to NOTCH1 mutational status.
Five-year probability of EFS (A) and 5-year cumulative incidence of nonresponse/progression/relapse (B), according to NOTCH1 mutational status.
Bettina R. Bonn et al. Blood 2013;121:
©2013 by American Society of Hematology

4. Five-year probability of EFS (A) and 5-year cumulative incidence of nonresponse/progression/relapse (B), according to LOH6q status.
Five-year probability of EFS (A) and 5-year cumulative incidence of nonresponse/progression/relapse (B), according to LOH6q status.
Bettina R. Bonn et al. Blood 2013;121:
©2013 by American Society of Hematology