Presentation is loading. Please wait.

Presentation is loading. Please wait.

Pitx2 haploinsufficiency rescues Tbx5 haploinsufficiency in mice

Published byTyler Sharp Modified over 6 years ago

Similar presentations

Presentation on theme: "Pitx2 haploinsufficiency rescues Tbx5 haploinsufficiency in mice"— Presentation transcript:

1 Fig. 4. Pitx2 haploinsufficiency rescues Tbx5 haploinsufficiency in mice.
Pitx2 haploinsufficiency rescues Tbx5 haploinsufficiency in mice. (A) Relative transcript expression by qPCR in the left atria from Pitx2 and Tbx5 heterozygotes and Tbx5;Pitx2 compound heterozygotes. Data are means ± SEM normalized to R26CreERt2 mice (set as 1) (n = 11 R26CreERt2; n = 15 Tbx5fl/+;R26CreERt2; n = 4 Pitx2fl/+;R26CreERt2; n = 8 Tbx5fl/+;Pitx2fl/+;R26CreERt2). *P < 0.05, two-tailed t test. Experiments were performed in technical triplicate. (B) Representative Poincaré plot of RR interval versus the subsequent RR + 1 interval (n = 7 R26CreERt2, n = 6 Tbx5fl/+;R26CreERt2, n = 9 Pitx2fl/+;R26CreERt2, and n = 7 Tbx5fl/+;Pitx2fl/+;R26CreERt2). (C) P-wave duration and PR interval calculated from ambulatory telemetry ECG recordings from mice in (B). P values were determined by two-tailed t test. Data are means ± SEM. (D) Representative AP recordings from atrial myocytes isolated from R26CreERt2, Tbx5fl/+;R26CreERt2, Pitx2fl/+;R26CreERt2, and Tbx5fl/+;Pitx2fl/+;R26CreERt2 mice. RMP, APA, APD50, and APD90 repolarization were determined from n > 3 animals per group (n = 14 R26CreERt2 cells, n = 15 Tbx5fl/+;R26CreERt2, n = 14 Pitx2fl/+;R26CreERt2, and n = 13 Tbx5fl/+;Pitx2fl/+;R26CreERt2). P values were determined versus R26CreERT2 controls. Inappropriate depolarization P values were measured by two-tailed Fisher’s exact test; APD90 and APD50 were determined by two-tailed t test. (E) Pacing induction by intra-atrial pacing of R26CreERt2 (n = 10), Tbx5fl/+;R26CreERt2 (n = 7), Pitx2fl/+;R26CreERt2 (n = 5), and Tbx5fl/+;Pitx2fl/+;R26CreERt2 (n = 7) mice. P values were determined by two-tailed Fisher’s exact test. Rangarajan D. Nadadur et al., Sci Transl Med 2016;8:354ra115 Published by AAAS

Download ppt "Pitx2 haploinsufficiency rescues Tbx5 haploinsufficiency in mice"

Similar presentations

ECG Rhythm Interpretation Module I ECG Basics Share what you know, learn what you don’t.

ECG Rhythm Interpretation Module I ECG Basics Share what you know, learn what you don’t.
ECG Basics.

ECG Basics.
Fig. 1. TP is highly expressed in myeloma.

Fig. 1. TP is highly expressed in myeloma.
Fig. 6. Transgenic expression of αLNNd and mag in dyW/dyW mice improves muscle function, increases body weight, and prolongs life span. Transgenic expression.

Fig. 6. Transgenic expression of αLNNd and mag in dyW/dyW mice improves muscle function, increases body weight, and prolongs life span. Transgenic expression.
Fig. 1. IL-6 is associated with resistance to EGFR TKIs and is induced by stress hormones. IL-6 is associated with resistance to EGFR TKIs and is induced.

Fig. 1. IL-6 is associated with resistance to EGFR TKIs and is induced by stress hormones. IL-6 is associated with resistance to EGFR TKIs and is induced.
Fig. 1. Potent and selective down-regulation of KRAS mRNA and protein by AZD4785 in vitro and in vivo. Potent and selective down-regulation of KRAS mRNA.

Fig. 1. Potent and selective down-regulation of KRAS mRNA and protein by AZD4785 in vitro and in vivo. Potent and selective down-regulation of KRAS mRNA.
Fig. 5. Blocking LTB4 during initial lymphangiogenesis period abrogates the therapeutic benefit of LTB4 antagonism. Blocking LTB4 during initial lymphangiogenesis.

Fig. 5. Blocking LTB4 during initial lymphangiogenesis period abrogates the therapeutic benefit of LTB4 antagonism. Blocking LTB4 during initial lymphangiogenesis.
Fig. 5. Correlation between CD34+CD45RA−CD90+ cell dose, engraftment success, and onset of neutrophil/platelet recovery in nonhuman primates. Correlation.

Fig. 5. Correlation between CD34+CD45RA−CD90+ cell dose, engraftment success, and onset of neutrophil/platelet recovery in nonhuman primates. Correlation.
Transfer of miR-223 during neutrophil-epithelial cell interactions

Transfer of miR-223 during neutrophil-epithelial cell interactions
Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.

Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.
Fig. 4 Bacterial taxonomic groups that discriminate among RYGB-, SHAM-, and WMS-derived samples. Bacterial taxonomic groups that discriminate among RYGB-,

Fig. 4 Bacterial taxonomic groups that discriminate among RYGB-, SHAM-, and WMS-derived samples. Bacterial taxonomic groups that discriminate among RYGB-,
Fig. 8. Gene and protein changes in ALK-dependent STING pathways in human sepsis. Gene and protein changes in ALK-dependent STING pathways in human sepsis.

Fig. 8. Gene and protein changes in ALK-dependent STING pathways in human sepsis. Gene and protein changes in ALK-dependent STING pathways in human sepsis.
Fig. 3. Antimicrobial activity is detected in diverse strains of CoNS and not predictable at the species level. Antimicrobial activity is detected in diverse.

Fig. 3. Antimicrobial activity is detected in diverse strains of CoNS and not predictable at the species level. Antimicrobial activity is detected in diverse.
Fig. 5. Correlation of tail and long bone growth velocities with Cxm serum concentrations in mice. Correlation of tail and long bone growth velocities.

Fig. 5. Correlation of tail and long bone growth velocities with Cxm serum concentrations in mice. Correlation of tail and long bone growth velocities.
Fig. 1. BCAS1 expression identifies newly generated oligodendrocytes.

Fig. 1. BCAS1 expression identifies newly generated oligodendrocytes.
Fig. 2 miRNA181a targets NFAT5 in human CD4+ T cells.

Fig. 2 miRNA181a targets NFAT5 in human CD4+ T cells.
Fig. 2. dAST using dPCR is robust to the presence of high concentrations of commensal bacteria due to the specificity of NA amplification. dAST using dPCR.

Fig. 2. dAST using dPCR is robust to the presence of high concentrations of commensal bacteria due to the specificity of NA amplification. dAST using dPCR.
Fig. 1 Crohn’s disease association within the LRRK2 locus.

Fig. 1 Crohn’s disease association within the LRRK2 locus.
Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.

Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.
Fig. 2 Maraba treatment results in complete responses in the window of opportunity setting. Maraba treatment results in complete responses in the window.

Fig. 2 Maraba treatment results in complete responses in the window of opportunity setting. Maraba treatment results in complete responses in the window.

Similar presentations

Ads by Google