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Updates and Perspectives on Third-Generation EFGR TKIs in Advanced NSCLC.

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Presentation on theme: "Updates and Perspectives on Third-Generation EFGR TKIs in Advanced NSCLC."— Presentation transcript:

1 Updates and Perspectives on Third-Generation EFGR TKIs in Advanced NSCLC

2

3 Third-Generation EFGR TKIs in Advanced NSCLC

4 Osimertinib

5 AURA Study: Phase 2 Expansion Cohort in First Line Patients Results

6 Osimertinib – Adverse Events

7 FLAURA Trial: Osimertinib vs Gefitinib or Erlotinib in Treatment-Naive Patients

8 EGFR C797S -- Resistance to Osimertinib

9 BLOOM Phase 1 Trial: Osimertinib Activity in Leptomeningeal Disease From NSCLC

10 BLOOM Phase 1 Trial -- Results

11 Olmutinib (BI 1482694) in Patients With T790M+ Advanced NSCLC

12 Olmutinib (BI 1482694) -- Results

13 Rociletinib for EGFR T790M+ NSCLC

14 ASP8273 (300 mg) in EGFR+ NSCLC: Interim Results

15 EGFR Exon 20 Insertions in NSCLC

16 EGF816: in EGFR Advanced NSCLC T790M+ Patients

17 Patients Who Have Progressed on Third-Generation EGFR TKIs

18 Ongoing Trials

19 Biomarker Testing in Advanced NSCLC

20 Applications of Liquid Biopsy

21 Limitations to Plasma-Based Testing

22 Conclusions

23 Abbreviations

24 Abbreviations (cont)


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