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Volume 119, Issue 3, Pages (September 2000)

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Presentation on theme: "Volume 119, Issue 3, Pages (September 2000)"— Presentation transcript:

1 Volume 119, Issue 3, Pages 670-676 (September 2000)
Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism  Mohamed Sagar, Gunnel Tybring, Marja–Liisa Dahl, Leif Bertilsson, Rein Seensalu  Gastroenterology  Volume 119, Issue 3, Pages (September 2000) DOI: /gast Copyright © 2000 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Median 24-hour intragastric pH before treatment (day 0) and after 8 days of 20 mg omeprazole administered orally once daily in the 3 genotypic groups of patients with and without H. pylori infection (top, wt/wt; middle, wt/mut; bottom, mut/mut; 2 patients). Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Median 24-hour pH curves on day 8 of omeprazole treatment (20 mg) in homozygous (wt/wt, thin line) and heterozygous (wt/mut, bold line) EM subjects. The dashed lines represent pretreatment (day 0) pH profiles in the (A) H. pylori–positive and (B) H. pylori–negative individuals. (C) Individual data for the 2 H. pylori–positive PM subjects (mut/mut) on day 8. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions


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