1. Ovarian Cancer Facts and Figures
GEMSTONE Educational Module
Last Update: April 2, 2018
GEMSTONE, a committee of ovarian cancer experts, provided direction and approval of the material in this educational resource. TESARO, Inc. provided writing and organizational support to GEMSTONE in the generation of this material.

2. Module Objectives
Describe public health burden of ovarian cancer in United States
Review shifting trends in ovarian cancer incidence and mortality
Identify how incidence and mortality differ across patient demographics
Compare NIH funding levels for ovarian and breast cancers
NIH, National Institutes of Health.

3. Module Outline Ovarian Cancer Statistics
Risk Factors and Epidemiology by Ethnicity
Current Needs
Summary and Unresolved Questions

4. Ovarian Cancer Statistics

5. Ovarian Cancer Is Relatively Rare Compared With Other Cancers
Incidence in United States
222,060
Prevalence in United States
11.7
22,240
new cases per 100,000 women per yeara
2018 total new diagnoses2
based on diagnoses between 1975 and 2014b
1.3%
2.8%
Proportion of all new cancer diagnoses in United States
Proportion of all US cancer diagnoses in women up to 2014c
A woman’s lifetime risk of getting ovarian cancer is about 1 in 782
a Age-adjusted data from b Derived from maximum limited-duration prevalence between 1975 and 2014 for all years since diagnosis and US Census Bureau data. c Complete prevalence of ovarian cancer (222,060 in the United States between 1975 and 2014) divided by the complete prevalence of all cancers in women (7,866,096 in the United States between 1975 and 2014).
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed April 2, American Cancer Society. What Are the Key Statistics About Ovarian Cancer?. Last revised January 5, Accessed April 2, 2018.

6. Ovarian Cancer Is the Most Lethal Gynecologic Cancer
Mortality in United States
Overall estimated 5-year survival in United States
46.5%
7.4
14,070
deaths per 100,000 women per yeara
2018 estimated total deaths2
92.5
73.0
28.9
15.0
20.0
60.0
Most ovarian cancer diagnoses occur after metastasis, when survival rates decline
Estimated 5-year survival
Percentage of diagnosed cases by stage
a Age-adjusted data from
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed April 2, American Cancer Society. What Are the Key Statistics About Ovarian Cancer?. Last revised January 5, Accessed April 2, 2018.

7. Epidemiological Trends Show a Decline in Ovarian Cancer Incidence and Mortality
Over the last decade, ovarian cancer incidence has declined by 1.9% on average each year, while mortality has declined by 2.2% on average each year
New Cases
2014
Number per 100,000 Women
Deaths
2014
Year
National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed April 2, 2018.

8. Mortality of ovarian cancer1 vs breast cancer2
Ovarian Cancer Mortality Has Remained Relatively Stable Compared With Breast Cancer
Mortality of ovarian cancer1 vs breast cancer2
Breast cancer
Deaths per 100,000 Women
Ovarian cancer
Year
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed April 2, National Cancer Institute. SEER Cancer Stat Facts: Female Breast Cancer. Published April Accessed April 2, 2018.

9. Median Age of Ovarian Cancer Diagnosis Is 63 Years
Age distribution
Median age at ovarian cancer diagnosis1
63 years
Median age at ovarian cancer diagnosis in women with a BRCA1/2 mutation2
BRCA1
52 years
BRCA2
59 years
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed April 2, Norquist BM, et al. JAMA Oncol. 2016;2(4):

10. Median Age of Ovarian Cancer Death Is 70 Years
Age distribution
Median age at death due to ovarian cancer
70 years
National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed April 2, 2018.

11. Risk Factors and Epidemiology by Ethnicity

12. Hereditary Cancer Syndromes
Risk and Protective Factors Associated With Likelihood of Developing Epithelial Ovarian Cancer
Risk Factors
Protective Factors
Age
Obesity
Full-Term Pregnancy
OCP Use
Breast- feeding
Fertility Drugs
Hereditary Cancer Syndromes
Tubal Ligation
Hysterectomy
OCP, oral contraceptive pills.
American Cancer Society. What Are the Risk Factors for Ovarian Cancer?. cancer/causes-risks-prevention/risk-factors.html. Last revised February 4, Accessed April 2, 2018.

13. Incidencea by Ethnicity Mortalityb by Ethnicity
Ovarian Cancer Incidence and Mortality Rates Are Highest in White Women But Affect All Ethnicities
Incidencea by Ethnicity
Mortalityb by Ethnicity
All Races
White
Black
Asian/ Pacific Islander
American Indian/ Alaska Native
Hispanic
Non-Hispanic
11.7
12.2
9.4
9.5
10.6
11.8
7.4
7.7
6.4
4.4
6.2
5.4
7.6
Age-adjusted data from
a Number of new cases per 100,000 persons. b Number of deaths per 100,000 persons.
National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed April 2, 2018.

14. Black Women With Ovarian Cancer Have a Lower 5-Year Survival Rate Than White Women
5-year survival in gynecologic cancers by race ( , all stages): 69 84 68 82 46 46
5-Year Survival (%) 57 62 36
Siegel RL, et al. CA Cancer J Clin. 2017;67(1):7-30.

15. Current Needs

16. NIH Funding: Ovarian & Breast Cancer
Additional Research Funding Is Necessary to Improve Outcomes for Women With Ovarian Cancer
NIH Funding: Ovarian & Breast Cancer
Ovarian Cancer
$144 million
Breast Cancer
$656 million
Total NIH Spending, 2016 (in millions)
Ovarian Cancer
Breast Cancer
Annual mortalitya 51,103
US prevalence ratea 0.4%
US prevalence ratea 1.6%
Annual mortalitya 14,972
total funded projects
319
total funded projects
1693
a Derived from consistent and nationally representative 2015 disease statistics provided by National Center for Heath Statistics at the Center for Disease Control and Prevention.
NIH, National Institutes of Health.
National Institutes of Health. Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC). Research Portfolio Online Reporting Tools (RePORT). Published July 3, Accessed April 2, 2018.

17. Summary and Unresolved Questions

18. Module Summary
Ovarian cancer is relatively rare but relatively lethal1
Survival is correlated with extent of disease spread at diagnosis1
Estimated 5-year survival in United States:
Localized disease: 92.5%
Distant disease: 28.9%
Ovarian cancer mortality and incidence are declining slightly1
Certain factors may affect risk for ovarian cancer and potential prognosis1,2
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed April 2, American Cancer Society. What Are the Risk Factors for Ovarian Cancer?. Last revised February 4, Accessed April 2, 2018.

19. Unresolved Questions
How can women modify their diet and lifestyle choices to decrease risk of ovarian cancer?
How does obesity affect risk of ovarian cancer?
How can we improve screening and earlier detection?

20. GEMSTONE
GEMSTONE, a committee of ovarian cancer experts, provided direction and approval of the material in this educational resource. TESARO, Inc. provided writing and organizational support to GEMSTONE in the generation of this material.
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