Presentation is loading. Please wait.

Presentation is loading. Please wait.

Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X- linked thrombocytopenia  Elena Crestani, MD, Stefano Volpi, MD, Fabio.

Published byEmory Morgan Modified over 6 years ago

Similar presentations

Presentation on theme: "Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X- linked thrombocytopenia  Elena Crestani, MD, Stefano Volpi, MD, Fabio."— Presentation transcript:

1 Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X- linked thrombocytopenia  Elena Crestani, MD, Stefano Volpi, MD, Fabio Candotti, MD, Silvia Giliani, PhD, Lucia Dora Notarangelo, MD, Julia Chu, MD, Juan Carlos Aldave Becerra, MD, David Buchbinder, MD, Janet Chou, MD, Raif S. Geha, MD, Maria Kanariou, MD, Alejandra King, MD, Cinzia Mazza, PhD, Daniele Moratto, PhD, Robert Sokolic, MD, Elizabeth Garabedian, RN, MSLS, Fulvio Porta, MD, Maria Caterina Putti, MD, Rima H. Wakim, MD, Erdyni Tsitsikov, PhD, Sung-Yun Pai, MD, Luigi D. Notarangelo, MD  Journal of Allergy and Clinical Immunology  Volume 136, Issue 5, Pages e3 (November 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A and B, Heat map of IgG (Fig 1, A) and IgA (Fig 1, B) autoantibodies in patients with XLT and those with WAS. For each self-antigen, a colorimetric representation of RAR in each sample is shown according to the scale depicted at the top. C and D, Autoantibodies with significantly increased reactivity in patients with WAS and those with XLT, respectively, compared with those in healthy donors (HD). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 Percentage of self-antigens for which there were positive IgG (A) and IgA (B) autoantibody levels. Five hundred eighty autoantibodies were demonstrated in patients with WAS and those with XLT. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E2 IgG (A) and IgA (B) serum levels in multireactive and paucireactive patients with WAS/XLT. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E3 A and B, Frequency of positivity for the 25 most common autoantibodies. C, RAR values for 2 IgG autoantibodies (to fibrinogen IV and mitochondrial antigen) with significantly increased levels in patients with XLT and those with WAS compared with levels in healthy control subjects (HD). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X- linked thrombocytopenia  Elena Crestani, MD, Stefano Volpi, MD, Fabio."

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficiencies Itai M. Pessach, MD, PhD, Jose Ordovas-Montanes, BA,

Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficiencies Itai M. Pessach, MD, PhD, Jose Ordovas-Montanes, BA,
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Plasmacytoid dendritic cell depletion in DOCK8 deficiency: Rescue of severe herpetic infections with IFN-α 2b therapy  Sevgi Keles, MD, Haifa H. Jabara,

Plasmacytoid dendritic cell depletion in DOCK8 deficiency: Rescue of severe herpetic infections with IFN-α 2b therapy  Sevgi Keles, MD, Haifa H. Jabara,
Risk of an asthma exacerbation after bariatric surgery in adults

Risk of an asthma exacerbation after bariatric surgery in adults
Clarification concerning amoxicillin skin testing

Clarification concerning amoxicillin skin testing
Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S
Clinical and genetic diagnosis of warts, hypogammaglobulinemia, infections, and myelokathexis syndrome in 10 patients  Laura Tassone, PhD, Lucia D. Notarangelo,

Clinical and genetic diagnosis of warts, hypogammaglobulinemia, infections, and myelokathexis syndrome in 10 patients  Laura Tassone, PhD, Lucia D. Notarangelo,
High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,
Serum cytotoxic T lymphocyte–associated antigen 4 in Hymenoptera venom allergy and its modulation by specific immunotherapy  Daniele Saverino, BS, Anna.

Serum cytotoxic T lymphocyte–associated antigen 4 in Hymenoptera venom allergy and its modulation by specific immunotherapy  Daniele Saverino, BS, Anna.
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment  Federica Cattaneo, MD, Mike.

Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment  Federica Cattaneo, MD, Mike.
Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Recurrent anaphylaxis linked to pantoprazole

Recurrent anaphylaxis linked to pantoprazole
Long-term immune reconstitution and clinical outcome after stem cell transplantation for severe T-cell immunodeficiency  Evelina Mazzolari, MD, Concetta.

Long-term immune reconstitution and clinical outcome after stem cell transplantation for severe T-cell immunodeficiency  Evelina Mazzolari, MD, Concetta.
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation  Teresa Song, BS, Ana B. Pavel, PhD, Huei-Chi Wen, MD, PhD,

An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation  Teresa Song, BS, Ana B. Pavel, PhD, Huei-Chi Wen, MD, PhD,

Similar presentations

Ads by Google