1. Immunodeficiencies

2. Diseases caused by defective immune response
Immunodeficiencies
Diseases caused by defective immune response
Disorders of development and/or function of one or more components of the immune system
Increased susceptibility to infection and certain types of cancer

7. Immunodeficiencies
Congenital (primary)
Acquired (secondary)

8. Congenital (primary) immunodeficiencies

9. Congenital immunodeficiencies
Caused by genetic defects...
in lymphocyte maturation
in lymphocyte activation and function
in innate immunity
Other disorders associated with immunodeficiencies

10. Congenital immunodeficiencies cause by defects in lymphocyte maturation

11. B cell immunodeficiencies (agammaglobulinemias)
Severe combined immunodeficiencies (SCIDs)
T cell immunodeficiencies
Defective thymic development
(DiGeorge's syndrome)

12. Congenital immunodeficiencies cause by defects in lymphocyte activation and function

14. CD40L function in immune response

16. Congenital immunodeficiencies cause by defects in innate immunity

17. Defects of innate immunity

18. Defects of innate immunity

19. Defects of innate immunity

20. Immunodeficiencies therapy
Congenital (primary)
Replacement (e.g. immunoglobulins)
Bone marrow transplantation
Gene therapy
Prophylaxis