1. THE STORY OF FOX VACCINATION AGAINST RABIES USING A RECOMBINANT VACCINIA-RABIES VIRUS Paul-Pierre PASTORET World Organisation for Animal Health

6. PREVIOUS STORIES
THE FIRST ATTEMPTS TO ELIMINATE FOX RABIES INVOLVED CULLING FOXES BY HUNTING AND GASSING THE DENS; THEY WERE UNSUCCESSFUL

8. PREVIOUS STORIES 2
THE SECOND STEP WAS TO VACCINATE FOXES AGAINST RABIES BY THE ORAL ROUTE USING ATTENUATED STRAINS OF RABIES VIRUS SUCH AS SADB19 STRAIN

9. PREVIOUS STORIES 3
CONVENTIONALLY ATTENUATED RABIES VIRUS STRAINS ARE STILL PATHOGENIC FOR SOME WILDLIFE SPECIES
UNKNOWN SAFETY FOR MAN

10. PREVIOUS STORIES 4 IN BELGIUM:
FIRST TRIALS IN CONFINEMENT WITH ATTENUATED STRAIN SADB19
STRONG OPPOSITION OF VETERINARY AUTHORITIES
LARGE-SCALE TRIAL WITH SADB19

12. THERE WAS ROOM FOR A RECOMBINANT VIRUS THAT COULD BE ADMINISTERED BY THE ORAL ROUTE TO WILDLIFE SPECIES

14. THE RECOMBINANT VACCINIA-RABIES VACCINE STORY
QUALITY
EFFICACY
SAFETY FOR THE FOX
SAFETY FOR OTHER SPECIES SHARING THE SAME ECOSYSTEM

16. MORE THAN SEVENTY SPECIES TESTED FOR SAFETY NOWADAYS
SAFETY FOR HUMANS
SAFETY FOR BADGERS
SAFETY FOR WILD BOARS
MORE THAN SEVENTY SPECIES TESTED FOR SAFETY NOWADAYS

18. THE RECOMBINANT VACCINIA-RABIES VACCINE STORY 2
WILDLIFE MUST BE VACCINATED BY THE ORAL ROUTE; THE DELIVERY SYSTEM (BAITING) IS OF PRIMARY IMPORTANCE

22. THE RECOMBINANT VACCINIA-RABIES VACCINE STORY 3
FIELD TRIALS:
A SMALL AREA ON A MILITARY CAMP
A LARGER AREA IN A CONTAMINATED AREA (2000 km2)
THE USE OF THE VACCINE ON THE WHOLE CONTAMINATED AREA IN BELGIUM

24. THE RECOMBINANT VACCINIA-RABIES VACCINE STORY 4
SURVEILLANCE STUDIES:
COLLECTING DEAD FOXES
RABIES DIAGNOSIS
COLLECTING SAMPLES FROM OTHER WILDLIFE SPECIES
TETRACYCLINE DETECTION

26. THE STORY OF THE RECOMBINANT VACCINIA-RABIES VACCINE 5
THE RESULTS :
COMPLETE ELIMINATION OF WILDLIFE RABIES IN BELGIUM
SHARP DECREASE OF HUMAN POST-EXPOSURE TREATMENTS
ELIMINATION OF RABIES IN IN- CONTACT DOMESTIC ANIMALS
INCREASE OF FOX POPULATION