1. Disseminated pyoderma gangrenosum: Role for vascular endothelial growth factor and hypoxia inducible factor-2 
Ramon Alvin Chua, MD, Jamie Mackelfresh, MD, Cynthia Cohen, MD, Vijay Varma, MD, Levi Fried, BS, Jack L. Arbiser, MD, PhD 
Journal of the American Academy of Dermatology 
Volume 61, Issue 4, Pages (October 2009)
DOI: /j.jaad
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

2. Fig 1
A, Representative skin lesion upon admission, showing deep ulceration and heaped up edges. B, Computed tomography scan revealing splenic hypodensities. C, Histology of the skin lesion, representing hematoxylin–eosin staining of the skin lesion. D, Immunohistochemistry for angiopoietin-2. E, Immunohistochemistry for vascular endothelial growth factor. F, Immunohistochemistry for hypoxia inducible factor-2a. (C-F, Original magnification: ×40.)
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

3. Fig 2
Proposed model of neutrophilic amplification in pyoderma gangrenosum. Neutrophils with a defect in suppression of reactive oxygen are attracted to the site of cutaneous injury by the innate immune system. The neutrophil, which does not resolve inflammation upon appropriate physiologic stimuli, continues to recruit additional neutrophils, amplifying the pathologic process.
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions