1. Volume 144, Issue 5, Pages 903-911.e3 (May 2013)
A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome- Diarrhea: Effects on Bowel Frequency and Intestinal Function 
Maria I. Vazquez–Roque, Michael Camilleri, Thomas Smyrk, Joseph A. Murray, Eric Marietta, Jessica O'Neill, Paula Carlson, Jesse Lamsam, Denise Janzow, Deborah Eckert, Duane Burton, Alan R. Zinsmeister 
Gastroenterology 
Volume 144, Issue 5, Pages e3 (May 2013)
DOI: /j.gastro
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2. Figure 1
(A) Diet effect on stool frequency (*P = .04), form, and ease of passage; the effect on stool frequency was greater in HLA-DQ2– or HLA-DQ8–positive patients (P = .019). (B) Mean bowel movements per day during 14-day baseline and 28-day diet treatment periods in each patient randomized to gluten-free and gluten-containing diets. HLA-DQ2/8–negative patients are indicated by the open symbols.
Gastroenterology  , e3DOI: ( /j.gastro )
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3. Figure 2
Small intestinal and colonic permeability by the cumulative (A) mannitol and (B) lactulose excretion at 0–2 h and 8–24 h, respectively. There was increased small intestinal permeability with GCD, as shown by both cumulative mannitol excretion and the lactulose-to-mannitol ratio (ITT analysis, #P = .028 and P = .0012). The effect on lactulose excretion was borderline significant (*P = .097).
Gastroenterology  , e3DOI: ( /j.gastro )
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4. Figure 3
In vitro cytokine production by PBMCs in response to stimulation with either rice (control) or gluten. Note the increased production of IL-10 and GM-CSF, and the borderline increased TNF-α in response to gluten, compared with rice.
Gastroenterology  , e3DOI: ( /j.gastro )
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5. Supplementary Figure 1
Trial flow according to the CONSORT guidelines and baseline demographics showing comparability of the 2 diet treatment groups.
Gastroenterology  , e3DOI: ( /j.gastro )
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