1. Po’RSILDOQ YARA , TERINING VIRUSLI DERMATOZLARI maruzalar
Teri tanosil kasalliklar kafedrasi
Teri tanosil kasalliklar fani
Po’RSILDOQ YARA , TERINING VIRUSLI DERMATOZLARI maruzalar

2. *infekciyalar ( viruslar ) * Almashuv –endokrin uzgarishlar
Po’rsildoq yara kasalligi –surunkali kechuvchi , yemonsifatli,autoimmun dermatoz Terida , shilliq qavatlarda akantolisis natijasida pufaklar paido bo’ladi , bir biri bilan qushilib , butun teri buyicha tarqalishadi .
Olib keluvchi omillar
*infekciyalar ( viruslar )
* Almashuv –endokrin uzgarishlar
Asab va tomirlar tizimida uzgarishlar
Suv –tuzli almasyuvining buzilishi
Buyrak osti bezini faoliyatini buzilishi

3. Patogenez : *epidermisning tikanaksimon qavatiga nomalum zararlanuvchi agentning ta’siri *yadroli DNK tuplanishi * Tikanaksimon qavatining xujayralarning va xujayralar aro moddalarning antigaen strukturasini uzgarishi * tikanaksimon qavatida Ig G sinfidagi antitanachalarning tuplanishi va xujayralarning mtmbranasiga ta’sir qilishi *Proteolitik fermentlarni chiqishi desmosomslarning buzilishi Proteoliz sistemasining aktivaciyasi , akantoliz rivojlanishi Pa

4. Tasnifi Laboratoriya tashhisi Vulgar yeki oddiy Тarqaluvchi Bargsimon
Seboreyali
HARAKTERLI BELGILAR
Simptom Nikolskogo
Simptom Asbo-Hanzena
Laboratoriya tashhisi
Tcank hujayralarning mikroskopiya tekshiruvi
Biopsiya orqali gistologiya tekshiruvi
Immunofluorescenciya reakciyasi

5. Oddiy terida va shilliq qavatlarda monofakal pufaklar
Po’rsildoq yaraning klinik manzarasi
Oddiy terida va shilliq qavatlarda monofakal pufaklar
Тarqaluvchi – shilinishlar periferiya bo’ylab o’sadi , ustida yemon hidli vegetaciyalar kuzatiladi .
Bargsimon –shilliq qavatlar shikastlanadi , shilinishlar ustida qat-qat qaloqlar paydo buladi
Seboreyali turi – Po’rsildoq yara , seboreya, qizil yuguruk alomatlari kuzatiladi

6. Differencial tashhis Bullez pemfigoid Dermatoz Duringa
Kup shakkli ekssudativ eritema

7. DAVOLASH Kortikosteroidlar Geparin Immunostimulatorlar
Antistafilokkokli plazma
Qon quyish ,gemosorbciya
Plazmafarez
Parhez
Kaliy vositalari
Quvvatlaydigan terapiya

8. DERMATIT DURINGA
Surunkali kechuvchi pufakli polimorf dermatoz .Toshmalar gerpessimon joylashadi ,jarayenlarda achishish ,og’riq kuzatiladi

9. Olib keluvchi omillar
Donli usimliklarning gluteniga , galoidlarga uta sezuvchanligi
Malabsorbciya ( glutenli enteropatiya )
Neyroendokrin uzgarishlar
Homiladorlik
Menopauza
Infekciyalar

10. Patogenez Kleykovina gluteniga uta sezuvchanlik
Ingichka ichakning tuqimali elementlarning antigeniga immun komplexlarni hosil bulishi
Dermaning surgichlarida immunoglobulinlarning tuplanishi
Subepidermal pufaklar , pufakchalar hosil bulishi
Qon zardobining antioksidant faolligini susayishi

11. GDDbelgilari Surunkali qaytalanuvchi kechishi
Polimorf guruchlashgan toshmalar
Qichishish , achishish

12. Klinik turlari -
Mayda pufakli
Yirik pufakli
Toshmalar guruh bo’lib joylashgan eritema fonida papulez , urtikar , vezikulez , bullez toshmalar

13. Laboratoriya diagnostokasi
Qonda eozinofiliya / 30% quproq / Qonda gipoalbuminemiya Globulin frakciyasini ko’payishi
Surtmalarda - eozinofiliya
Yadasson sinamasi musbat

14. Profilaktika Bemorlarga mumkin emas Guruch , arpa ,bugdoy
Тarkibida yod bor mahsulotlari / dengiz karami, kapusta /

15. Virusli kasalliklar Klassifikaciya
Oddiy gerpes / pufakchali temitatki /
O’ rab oluvchi temitatki
Sugallar
Кontagioz mollusk

16. Klinika
Oddiy gerpesda –eritematoz fonida guruh bo’lib joylashgan kupkamerali pufakchalar , gajimdor eroziyalar
O’rab oluvchi temiratkida innervaciya buylab joylashishi
Ogriq ,achishish ,qichishish kuzatiladi

17. O’rab oluvchi temiratkining klinik turlari
Abortiv
Gemoragik
Bullez
Gangrenoz
Generalizaciyalangan

18. Diagnostika
Harakterli klinik turi
Laboratoriya diagnostikasi

19. Davolash Virusga qarshi dori –vositalar Malhamlar Immunostimulaciya
Vitaminoterapiya
Parhez

20. During dermatiti

21. ogiz shilliq qavatining shikastlanishi

22. Diagnostika Nikolskiy simptomi
Citologik usul va PIF yerdamida akantolitik (Tcank ) hujayralarini aniqlash

23. The subject: «Pemphigus and viral dermatosis».
    Pemphigus- malignant taking chronic autoimmune dermatosis. Accompanied by the development of vesicular in the skin and mucous membranes. The vesicular tend to merge and spread on the skin. There has been a marked toxemia. Without corticosteroid therapy ends fatal. Risk factors: infection, exchange-endocrine disruption. Pemphigus is an autoimmune disease. Diseases in the group bullosis dermatosis: - pemphigus, dermatitis herpetiformis Duhring, non acantholyticus pemphigus (Lever pemfigoid). - Signs of determining the true pemphigus: - long wave (progressive without treatment) within, monomorphis cystic rashes on the skin and mucous membranes; autoimmune pathogenesis, with the development of blistering acantholysis. Classification of true pemphigus: - vulgar (normal); vegetating - fuliaccis (exfoliate) - seborrhoicus. Symptoms characteristic of pemphigus: - Nicholas symptom - a symptom of Asbo-Hansen. The laboratory methods used to confirm the diagnosis of pemphigus: take a print from the center of smear and microscopic study of the existence of cells Ttsanka (acantholyticals cells) - histological study by biopsy sampling - a method of direct immunnoflyuorestsentsii. The main drugs used in the treatment of pemphigus - corticosteroid drugs.
HERPETIFORMIS dermatosis DUHRING - Chronic papula dermatosis with polymorphic herpethyformis location elements , burning and pain in the lesion sites, developing as a result of violations of absorption in the small intestine (malabsorption syndrome) and the formation of immunoallergic reactions.Faktory risk-_high sensitivity to glutens cereal plants, and halogens, the syndrome malabsorption (glyutenens entheropatiya), neuroendocrine disorders, pregnancy, menopause, disease. Pathogenesis - Hypersensitivity to gluten Clinic - Clinical rash polymorphic forms big pemphigus, small pemphigus. - The main features that define dermatitis Duhring: - chronic recurrence dermal - polymorphic eruption grouped-intense itching, burning feeling, paresthesia;         Primary elements of a rash dermatitis Duhring: - erythematous - papulosis - urticalis - vezikularis - bullosis.Changes in the blood, which can be detected in patients with dermatitis Duhring: - eosinophilia of more than 30% - gipoalbuminemiya with going up- globulin Thrace.  Virus diseases of skin. Diseases of viral etiology: - herpes simplex (herpes vesicularis) - shingles (Herpes zoster); a wart, contagious mollusk, knots doilschits (false cow pox). Characteristic of localized herpes simplex: the wings of the nose, corners of mouth, the red border of lips, genitals, mucous in the mouth (thrush). Treatment of antiviral drugs