1. **This may be expedited depending on PRMC SOP
Study targets cancer patients under active tx or with evidence of disease currently
PRMC reviews**
**This may be expedited
depending on PRMC SOP
Study targets cancer survivors
Participants are at high risk of cancer* OR cancer is a study outcome
Study excludes cancer patients/survivors
Yes No
PRMC does not review
*Examples:
-lung CT study of lung cancer detection in smokers
-risk-reducing drug in women with BRCA1/2 mutations
-large population study of diet patterns and cancer incidence
Definition of “high risk”: incidence of cancer over the course of the study is expected to be higher than general population incidence