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Long-Range Intracortical Excitation Shapes Olfactory Processing

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Presentation on theme: "Long-Range Intracortical Excitation Shapes Olfactory Processing"— Presentation transcript:

1 Long-Range Intracortical Excitation Shapes Olfactory Processing
Minmin Luo  Neuron  Volume 72, Issue 1, Pages 1-3 (October 2011) DOI: /j.neuron Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Highly Simplified Schematics Illustrating the Neuronal Wiring Patterns in the Olfactory System The projection from the olfactory epithelium to the MOB conforms to the rule of “labeled-line” so that a given glomerulus receives converging input from OSNs expressing a specific OR and drives the excitation of an exclusive subset of mitral/tufted (M/T) cells. However, the projection of M/T cells to the piriform cortex becomes random and diffusive. Individual PNs integrate M/T inputs associated with scores of glomeruli. In addition, PNs extend long-range axonal outputs to excite other PNs and at the same time receive recurrent cortical inputs from thousands of PNs. GABAergic interneurons (INs) mediate both feed-forward and feedback inhibitions to stabilize the cortical circuit. GL, glomerular layer; Gr, granule cells; PG, periglomerular neurons. Neuron  , 1-3DOI: ( /j.neuron ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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