1. Schizophrenia Treatments With New Mechanisms of Action Are Emerging

2. Positive Symptoms of Schizophrenia

3. Negative Symptoms of Schizophrenia

4. Prevalence of Negative Symptoms in Schizophrenia

5. DSM-5 Criteria for Schizophrenia

6. Schizophrenia Time Course

7. Interactions Between Symptom Domains of Schizophrenia

8. Primary and Secondary Negative and Cognitive Symptoms in Schizophrenia Differential Diagnosis

9. The Effectiveness Triangle

10. Traditional Receptor-Drug Interaction Types

11. Novel Receptor-Drug Interaction Types

12. Adverse Events Considered by Patients to Have Most Negative Effect on Quality of Life

13. Dopaminergic Pathways

14. Long-Term Effects on Functioning in Schizophrenia Cariprazine

15. ENLIGHTEN-1: The First of Two Studies of ALKS 3831

16. Serotonergic Pathways

17. Long-Term Effects on Functioning in Schizophrenia Brexpiprazole

18. Evaluating Lu AF35700

19. Effects on Symptoms in Schizophrenia MIN-101

20. Evaluating Pimavanserin

21. Effects on Symptoms in Schizophrenia and Schizoaffective Disorder RP5063

22. Glutamatergic Pathways

23. Effects on Symptoms in Schizophrenia Lumateperone

24. GABA-ergic Pathways

25. Glutamate System

26. Take-Home Points

27. Abbreviations