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The Angiotensin II Type 2 Receptor for Pain Control

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Presentation on theme: "The Angiotensin II Type 2 Receptor for Pain Control"— Presentation transcript:

1 The Angiotensin II Type 2 Receptor for Pain Control
A.H. Jan Danser, Praveen Anand  Cell  Volume 157, Issue 7, Pages (June 2014) DOI: /j.cell Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Angiotensin II Formation and the Subsequent Activation of AT2 Receptors, Resulting in Either Hyperalgesia or Analgesia (A) The hyperalgesia pathway predominates in peripheral primary nociceptors and converges with the nerve growth factor-TRPV1 (transient receptor potential vanilloid subfamily member 1) pain pathway. (B) The mycolactone analgesia pathway may predominate in inflammatory cells and central nervous system neurons. PLA2, phospholipase A2; AA, arachidonic acid; COX-1, cyclooxygenase-1; PGE2, prostaglandin E2; TRAAK, TWIK-related, arachidonic acid-activated K+ channel. Cell  , DOI: ( /j.cell ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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