1. Odds ratios for use of NSAIDs within previous three months compared with controls
Drug used within 3 months of index date
Adjusted odds ratio* p
Celecoxib
1.21
0.11**
Rofecoxib
1.32
0.005
Other selective NSAIDs
1.27
0.046
Ibuprofen
1.24
<0.001
Diclofenac
1.55
Naproxen
0.04
Other nonselective NSAIDs
0.03
*Compared with no use of drug in past 3 years (odds ratio 1.00). Adjusted simultaneously for each NSAID, use of aspirin, statin, tricyclic antidepressant, selective serotonin reuptake inhibitor, ischemic heart disease, diabetes, hypertension, osteoarthritis, rheumatoid arthritis, smoking, obesity, and deprivation.
**Hippisley-Cox told heartwire the numbers of patients on celecoxib were low and "therefore we probably didn't have sufficient power to look at this drug."
Hippisley-Cox J and Coupland C. BMJ 2005; 330:
Further calls to reconsider CV safety of all NSAIDs [Rheumawire > News; Jun 9, 2005]